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The therapeutic effects of an oleanolic acid derivative in diet induced obesity

Conference Paper


Abstract


  • Purpose: Recently, studies have shown that pentacyclic triterpenes have

    anti-inflammatory effects in the brains of mice with obesity; a disorder

    where inflammation largely contributes to energy balance dysregulation.

    The purpose of this study was to: 1) Investigate for the first time if the

    oleanolic acid (OA) derivative, bardoxolone methyl (BM) has a more

    potent effect than ursolic acid (UA) and OA in reducing body weight in

    mice fed a high fat diet (HFD) for 10 weeks; 2) To analyse hypothalamic

    tissue of mice in this study to determine if UA, OA and BM improve

    key neuronal molecules involved in energy expenditure. Methods:

    12 week C57B1/6 male mice (n=70) were divided into 5 groups (low

    fat diet (LFD), HFD, HFD + UA, HFD + OA and HFD +BM). BM, UA

    and OA were administered in drinking water at a dosage of 10mg/kg.

    Signalling molecules involved in energy expenditure is being analysed

    using western blotting and Real time polymerase chain reaction (RTPCR).

    One and two way analysis of variance (ANOVA) and post-hoc

    Tukey-HSD test were performed for statistical analysis. Results: BM

    significantly prevented body weight gain in mice fed a HFD compared to

    the mice treated with OA and UA (p≤<0.05). Furthermore, BM reduced

    body weight (p≤<0.05). No differences in energy and water intake

    among the HFD groups have been found (p≥<0.05). The experiment is

    currently in progress and further data will be presented at the conference.

    Conclusion: The preliminary data have shown that BM significantly

    reduces body weight gain in mice fed a HFD (p≤<0.05). These results

    indicate that BM induced negative energy balance is influenced by the

    energy expenditure pathway of neuronal networks.

Authors


  •   Camer, Danielle (external author)
  •   Huang, Xu-Feng
  •   Yu, Yinghua

Publication Date


  • 2013

Citation


  • Camer, D., Huang, X. F. & Yu, Y. (2013). The therapeutic effects of an oleanolic acid derivative in diet induced obesity. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 111-111). Australia: ANS.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/901

Start Page


  • 111

End Page


  • 111

Place Of Publication


  • Australia

Abstract


  • Purpose: Recently, studies have shown that pentacyclic triterpenes have

    anti-inflammatory effects in the brains of mice with obesity; a disorder

    where inflammation largely contributes to energy balance dysregulation.

    The purpose of this study was to: 1) Investigate for the first time if the

    oleanolic acid (OA) derivative, bardoxolone methyl (BM) has a more

    potent effect than ursolic acid (UA) and OA in reducing body weight in

    mice fed a high fat diet (HFD) for 10 weeks; 2) To analyse hypothalamic

    tissue of mice in this study to determine if UA, OA and BM improve

    key neuronal molecules involved in energy expenditure. Methods:

    12 week C57B1/6 male mice (n=70) were divided into 5 groups (low

    fat diet (LFD), HFD, HFD + UA, HFD + OA and HFD +BM). BM, UA

    and OA were administered in drinking water at a dosage of 10mg/kg.

    Signalling molecules involved in energy expenditure is being analysed

    using western blotting and Real time polymerase chain reaction (RTPCR).

    One and two way analysis of variance (ANOVA) and post-hoc

    Tukey-HSD test were performed for statistical analysis. Results: BM

    significantly prevented body weight gain in mice fed a HFD compared to

    the mice treated with OA and UA (p≤<0.05). Furthermore, BM reduced

    body weight (p≤<0.05). No differences in energy and water intake

    among the HFD groups have been found (p≥<0.05). The experiment is

    currently in progress and further data will be presented at the conference.

    Conclusion: The preliminary data have shown that BM significantly

    reduces body weight gain in mice fed a HFD (p≤<0.05). These results

    indicate that BM induced negative energy balance is influenced by the

    energy expenditure pathway of neuronal networks.

Authors


  •   Camer, Danielle (external author)
  •   Huang, Xu-Feng
  •   Yu, Yinghua

Publication Date


  • 2013

Citation


  • Camer, D., Huang, X. F. & Yu, Y. (2013). The therapeutic effects of an oleanolic acid derivative in diet induced obesity. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 111-111). Australia: ANS.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/901

Start Page


  • 111

End Page


  • 111

Place Of Publication


  • Australia