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Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex

Conference Paper


Abstract


  • Purpose: We previously demonstrated significant reductions in

    sphingolipid levels and fatty acyl chain length in Parkinson’s disease

    (PD) grey matter anterior cingulate cortex (ACC). The aim of the present

    study was to explore whether these changes were sphingolipid-specific.

    Methods: Lipids were extracted from frozen ACC and occipital cortex

    (OCC) from PD patients (n=9) and age-matched controls (n=10), from

    the Sydney Brain Bank (supported by Neuroscience Research Australia,

    University of New South Wales and National Health and Medical

    Research Council of Australia). Total lipid fatty acid (FA) methyl esters

    were analysed by gas chromatography. Results: In both ACC and OCC

    14 FAs were identified. A significant decrease in total FA concentration

    (pmol/mg tissue) in PD was observed for ACC only (26%), with reductions

    in 10 individual FAs. FA relative abundance (mol%) was also only altered

    in ACC (significant changes in 11 FAs). The degree of change between

    PD and controls (mol%) was greater for sphingolipids than total FA

    composition, i.e. the mean mol% change for sphingolipids was 4% while

    for FAs it was 1%. Polyunsaturated FAs were increased in PD (6%)

    and peroxidation index was also increased (31%), indicating increased

    predicted susceptibility of PD ACC to peroxidative damage. Conclusion:

    Although changes in total FA composition were similar to sphingolipids

    in PD ACC, the degree of change in fatty acyl composition was much

    greater in sphingolipids, indicating that altered sphingolipid metabolism

    in PD may be particularly important. Altered global ACC FA composition

    may contribute to increased lipid peroxidation in PD.

Authors


  •   Abbott, Sarah K. (external author)
  •   Halliday, Glenda M. (external author)
  •   Garner, Brett

Publication Date


  • 2013

Citation


  • Abbott, S. K., Halliday, G. M. & Garner, B. (2013). Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 62-62). Australia: ANS.

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/349

Start Page


  • 62

End Page


  • 62

Abstract


  • Purpose: We previously demonstrated significant reductions in

    sphingolipid levels and fatty acyl chain length in Parkinson’s disease

    (PD) grey matter anterior cingulate cortex (ACC). The aim of the present

    study was to explore whether these changes were sphingolipid-specific.

    Methods: Lipids were extracted from frozen ACC and occipital cortex

    (OCC) from PD patients (n=9) and age-matched controls (n=10), from

    the Sydney Brain Bank (supported by Neuroscience Research Australia,

    University of New South Wales and National Health and Medical

    Research Council of Australia). Total lipid fatty acid (FA) methyl esters

    were analysed by gas chromatography. Results: In both ACC and OCC

    14 FAs were identified. A significant decrease in total FA concentration

    (pmol/mg tissue) in PD was observed for ACC only (26%), with reductions

    in 10 individual FAs. FA relative abundance (mol%) was also only altered

    in ACC (significant changes in 11 FAs). The degree of change between

    PD and controls (mol%) was greater for sphingolipids than total FA

    composition, i.e. the mean mol% change for sphingolipids was 4% while

    for FAs it was 1%. Polyunsaturated FAs were increased in PD (6%)

    and peroxidation index was also increased (31%), indicating increased

    predicted susceptibility of PD ACC to peroxidative damage. Conclusion:

    Although changes in total FA composition were similar to sphingolipids

    in PD ACC, the degree of change in fatty acyl composition was much

    greater in sphingolipids, indicating that altered sphingolipid metabolism

    in PD may be particularly important. Altered global ACC FA composition

    may contribute to increased lipid peroxidation in PD.

Authors


  •   Abbott, Sarah K. (external author)
  •   Halliday, Glenda M. (external author)
  •   Garner, Brett

Publication Date


  • 2013

Citation


  • Abbott, S. K., Halliday, G. M. & Garner, B. (2013). Global fatty acid composition is altered in Parkinson’s disease anterior cingulate cortex. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 62-62). Australia: ANS.

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/349

Start Page


  • 62

End Page


  • 62