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Expression of proteins within the nogo receptor complex are altered in the dorsolateral prefrontal cortex in schizophrenia

Conference Paper


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Abstract


  • Purpose: Schizophrenia is a severe neuropsychiatric disorder with an

    elusive aetiology, thought to result from abnormal brain development.

    Nogo is an oligodendrocyte bound molecule that signals by binding to

    its receptor NgR, located on axonal membranes that interacts with its

    co-receptors p75 or TROY and Lingo-1. Nogo signalling is responsible for

    CNS myelin regulation and neurite outgrowth during neurodevelopment,

    and plasticity in the mature brain. This study examined NgR, p75, TROY

    and Lingo-1 protein levels within the human dorsolateral prefrontal

    cortex (DLPFC) in schizophrenia. Methods: Human DLPFC matched

    case control samples (n=37/group) from the NSW Brain Bank Network

    were used to assess NgR, p75, TROY and Lingo-1 protein levels by

    immunoblotting. Results: N gR p rotein e xpression w as s ignificantly

    decreased by 16% (p<0.001) and Lingo-1 protein expression was

    significantly increased by 12% (p=0.006) in the DLPFC of schizophrenia

    subjects. Interestingly, neither the third receptor in this trimolecular

    receptor complex p75, nor its homolog TROY, showed any significant

    difference in levels of protein expression in schizophrenia subjects

    compared to controls (p=0.146 and p=0.500 respectively). There was

    a significant correlation between the protein levels of NgR and Lingo-1

    (r=-0.276, p=0.017); between Lingo-1 and p75 (r=0.263; p=0.023) and

    between NgR and TROY (r=0.329; p=0.004). Conclusion: This study

    shows strong evidence for the involvement of NgR/p75/Lingo-1 or

    NgR/TROY/Lingo-1 complex in schizophrenia, however further studies

    are required in order to investigate the implications of these proteomic

    alterations to the aetiology and symptomatology of schizophrenia.

Publication Date


  • 2013

Citation


  • Andrews, J., Newell, K. & Fernandez, F. (2013). Expression of proteins within the nogo receptor complex are altered in the dorsolateral prefrontal cortex in schizophrenia. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 49-49). Australia: ANS.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1912&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/899

Start Page


  • 49

End Page


  • 49

Abstract


  • Purpose: Schizophrenia is a severe neuropsychiatric disorder with an

    elusive aetiology, thought to result from abnormal brain development.

    Nogo is an oligodendrocyte bound molecule that signals by binding to

    its receptor NgR, located on axonal membranes that interacts with its

    co-receptors p75 or TROY and Lingo-1. Nogo signalling is responsible for

    CNS myelin regulation and neurite outgrowth during neurodevelopment,

    and plasticity in the mature brain. This study examined NgR, p75, TROY

    and Lingo-1 protein levels within the human dorsolateral prefrontal

    cortex (DLPFC) in schizophrenia. Methods: Human DLPFC matched

    case control samples (n=37/group) from the NSW Brain Bank Network

    were used to assess NgR, p75, TROY and Lingo-1 protein levels by

    immunoblotting. Results: N gR p rotein e xpression w as s ignificantly

    decreased by 16% (p<0.001) and Lingo-1 protein expression was

    significantly increased by 12% (p=0.006) in the DLPFC of schizophrenia

    subjects. Interestingly, neither the third receptor in this trimolecular

    receptor complex p75, nor its homolog TROY, showed any significant

    difference in levels of protein expression in schizophrenia subjects

    compared to controls (p=0.146 and p=0.500 respectively). There was

    a significant correlation between the protein levels of NgR and Lingo-1

    (r=-0.276, p=0.017); between Lingo-1 and p75 (r=0.263; p=0.023) and

    between NgR and TROY (r=0.329; p=0.004). Conclusion: This study

    shows strong evidence for the involvement of NgR/p75/Lingo-1 or

    NgR/TROY/Lingo-1 complex in schizophrenia, however further studies

    are required in order to investigate the implications of these proteomic

    alterations to the aetiology and symptomatology of schizophrenia.

Publication Date


  • 2013

Citation


  • Andrews, J., Newell, K. & Fernandez, F. (2013). Expression of proteins within the nogo receptor complex are altered in the dorsolateral prefrontal cortex in schizophrenia. 33rd Meeting of the Australian Neuroscience Society: Program, Abstracts & List of Registrants (pp. 49-49). Australia: ANS.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1912&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/899

Start Page


  • 49

End Page


  • 49