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Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities

Journal Article


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Abstract


  • A study of the hitherto unreported Stichoneuron halabalensis Inthachub led to the characterization of the known compounds (+)-α-tocopherol and (R)-(+)-

    goniothalamin; four known Stemona alkaloids, bisdehydoxystemoninine A (1), stemoninine (2), sessilistemonamine C (3) and sessilistemonamine A (4); and

    three new alkaloids, stichoneurine C (5), D (6) and E (7). The structures of these compounds were determined on the basis of their spectroscopic data. Alkaloid

    7 showed significant inhibitory activity against electric eel acetylcholinesterase (AChE) (IC50 5.90+0.084 μM), while goniothalamin and compounds 1 and 2

    showed significant inhibitory activities against human AChE (IC50 7.24+0.52, 5.52+0.13 and 3.74+0.09 μM, respectively).

Publication Date


  • 2013

Citation


  • Ramli, R., Lie, W. & Pyne, S. G. (2013). Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities. Natural Product Communications: an international journal for communications and reviews, 8 (6), 695-698.

Scopus Eid


  • 2-s2.0-84886439156

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2255&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1237

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 695

End Page


  • 698

Volume


  • 8

Issue


  • 6

Place Of Publication


  • United States

Abstract


  • A study of the hitherto unreported Stichoneuron halabalensis Inthachub led to the characterization of the known compounds (+)-α-tocopherol and (R)-(+)-

    goniothalamin; four known Stemona alkaloids, bisdehydoxystemoninine A (1), stemoninine (2), sessilistemonamine C (3) and sessilistemonamine A (4); and

    three new alkaloids, stichoneurine C (5), D (6) and E (7). The structures of these compounds were determined on the basis of their spectroscopic data. Alkaloid

    7 showed significant inhibitory activity against electric eel acetylcholinesterase (AChE) (IC50 5.90+0.084 μM), while goniothalamin and compounds 1 and 2

    showed significant inhibitory activities against human AChE (IC50 7.24+0.52, 5.52+0.13 and 3.74+0.09 μM, respectively).

Publication Date


  • 2013

Citation


  • Ramli, R., Lie, W. & Pyne, S. G. (2013). Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities. Natural Product Communications: an international journal for communications and reviews, 8 (6), 695-698.

Scopus Eid


  • 2-s2.0-84886439156

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2255&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1237

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 695

End Page


  • 698

Volume


  • 8

Issue


  • 6

Place Of Publication


  • United States