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Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena

Journal Article


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Abstract


  • An investigation of the essential oil (EO) and the crude MeOH extract of a Bhutanese variety of Ajania nubigena using GC/GC-MS and NMR found the

    following: a) one kg of the dried plant material contained 0.7% w/w EO; b) 44 of the 53 GC-FID peaks of the EO were identified with (3R,6R)-linalool oxide

    acetate (75.8 %) as the major constituent (chemotype II) and chamazulene as a new sub-chemotype; c) purification of the EO furnished (3R,6R)-linalool oxide

    acetate (1), chamazulene (2), (E)-2-(2,4-hexadiynylidene)-1,6-dioxaspiro[4,4]non-3-ene (3), and (Z)-2-(2,4-hexadinylidene)-1,6-dioxaspiro[4,4]non-3-ene (4);

    d) from the crude MeOH extract, four flavonoid compounds: 1-(4-hydroxyphenyl)propan-1-one (5), oxyanin B (6), luteolin (7) (major) and the luteolin-7-O--

    D-glucoside (8) were isolated; e) among the EO and pure compounds tested for biological activities, compound 7 exhibited a broad range of moderate

    antiplasmodial, cytoxicity and antimicrobial activities; c) compound 8 showed significant in vitro antiplasmodial activity against P. falciparum strains TM4/8.2

    and K1CB1 (multidrug resistant strain) and was identified as a potential antimalarial scaffold; and f) the in vitro antimicrobial and cytotoxicity activities were

    in alignment with the traditional medical uses of this plant and thus substantiate its use in Bhutanese traditional medicine.

Authors


  •   Wangchuk, Phurpa (external author)
  •   Keller, Paul A.
  •   Pyne, Stephen G.
  •   Korth, John (external author)
  •   Samten, - (external author)
  •   Taweechotipatr, Malai (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)

Publication Date


  • 2013

Citation


  • Wangchuk, P., Keller, P. A., Pyne, S. G., Korth, J., Samten, , Taweechotipatr, M., Rattanajak, R. & Kamchonwongpaisan, S. (2013). Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena. Natural Product Communications: an international journal for communications and reviews, 8 (6), 733-736.

Scopus Eid


  • 2-s2.0-84886406698

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2254&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1236

Number Of Pages


  • 3

Start Page


  • 733

End Page


  • 736

Volume


  • 8

Issue


  • 6

Abstract


  • An investigation of the essential oil (EO) and the crude MeOH extract of a Bhutanese variety of Ajania nubigena using GC/GC-MS and NMR found the

    following: a) one kg of the dried plant material contained 0.7% w/w EO; b) 44 of the 53 GC-FID peaks of the EO were identified with (3R,6R)-linalool oxide

    acetate (75.8 %) as the major constituent (chemotype II) and chamazulene as a new sub-chemotype; c) purification of the EO furnished (3R,6R)-linalool oxide

    acetate (1), chamazulene (2), (E)-2-(2,4-hexadiynylidene)-1,6-dioxaspiro[4,4]non-3-ene (3), and (Z)-2-(2,4-hexadinylidene)-1,6-dioxaspiro[4,4]non-3-ene (4);

    d) from the crude MeOH extract, four flavonoid compounds: 1-(4-hydroxyphenyl)propan-1-one (5), oxyanin B (6), luteolin (7) (major) and the luteolin-7-O--

    D-glucoside (8) were isolated; e) among the EO and pure compounds tested for biological activities, compound 7 exhibited a broad range of moderate

    antiplasmodial, cytoxicity and antimicrobial activities; c) compound 8 showed significant in vitro antiplasmodial activity against P. falciparum strains TM4/8.2

    and K1CB1 (multidrug resistant strain) and was identified as a potential antimalarial scaffold; and f) the in vitro antimicrobial and cytotoxicity activities were

    in alignment with the traditional medical uses of this plant and thus substantiate its use in Bhutanese traditional medicine.

Authors


  •   Wangchuk, Phurpa (external author)
  •   Keller, Paul A.
  •   Pyne, Stephen G.
  •   Korth, John (external author)
  •   Samten, - (external author)
  •   Taweechotipatr, Malai (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)

Publication Date


  • 2013

Citation


  • Wangchuk, P., Keller, P. A., Pyne, S. G., Korth, J., Samten, , Taweechotipatr, M., Rattanajak, R. & Kamchonwongpaisan, S. (2013). Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena. Natural Product Communications: an international journal for communications and reviews, 8 (6), 733-736.

Scopus Eid


  • 2-s2.0-84886406698

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2254&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1236

Number Of Pages


  • 3

Start Page


  • 733

End Page


  • 736

Volume


  • 8

Issue


  • 6