Skip to main content
placeholder image

The application of fungal beta-glucans for the treatment of colon cancer

Journal Article


Abstract


  • Mushrooms have been consumed for their health benefits for thousands of years in China, and the main active component was recently identified as beta-glucan. The immune-stimulating effect of beta-glucans has been well studied, and several beta-glucan receptors have been identified on the surface of immune cells. In addition, mushroom extracts with high levels of beta-glucans have also been shown to have direct cytotoxic effects on cancer cells, and beta-glucans are used for the treatment of cancer. This review summarizes the use of beta-glucans in colon cancer. Evidence has supported the idea that beta-glucans can decrease the size of xenografted colon cancer tumors via the stimulation of the immune system and direct cytotoxicity. Beta-glucans can also have synergistic effects with chemotherapeutic agents and other immune stimulators, and an innovative strategy is to use beta-glucans to deliver nanoparticles containing chemotherapeutic agents to the site of the colon cancer and, thus, improve the therapeutic efficacy.

UOW Authors


  •   Chen, Jiezhong
  •   Zhang, Xu Dong. (external author)
  •   Jiang, Zhengyi

Publication Date


  • 2013

Citation


  • Chen, J., Zhang, X. Dong. & Jiang, Z. (2013). The application of fungal beta-glucans for the treatment of colon cancer. Anti-Cancer Agents in Medicinal Chemistry, 13 (5), 725-730.

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/324

Number Of Pages


  • 5

Start Page


  • 725

End Page


  • 730

Volume


  • 13

Issue


  • 5

Abstract


  • Mushrooms have been consumed for their health benefits for thousands of years in China, and the main active component was recently identified as beta-glucan. The immune-stimulating effect of beta-glucans has been well studied, and several beta-glucan receptors have been identified on the surface of immune cells. In addition, mushroom extracts with high levels of beta-glucans have also been shown to have direct cytotoxic effects on cancer cells, and beta-glucans are used for the treatment of cancer. This review summarizes the use of beta-glucans in colon cancer. Evidence has supported the idea that beta-glucans can decrease the size of xenografted colon cancer tumors via the stimulation of the immune system and direct cytotoxicity. Beta-glucans can also have synergistic effects with chemotherapeutic agents and other immune stimulators, and an innovative strategy is to use beta-glucans to deliver nanoparticles containing chemotherapeutic agents to the site of the colon cancer and, thus, improve the therapeutic efficacy.

UOW Authors


  •   Chen, Jiezhong
  •   Zhang, Xu Dong. (external author)
  •   Jiang, Zhengyi

Publication Date


  • 2013

Citation


  • Chen, J., Zhang, X. Dong. & Jiang, Z. (2013). The application of fungal beta-glucans for the treatment of colon cancer. Anti-Cancer Agents in Medicinal Chemistry, 13 (5), 725-730.

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/324

Number Of Pages


  • 5

Start Page


  • 725

End Page


  • 730

Volume


  • 13

Issue


  • 5