Until recently, it was possible to state with some confi -
dence that there was no evidence of cannabis-related
brain damage in humans. There was some support from
the animal literature, but few human studies had been
conducted where the findings could not be explained
by methodological or other confounding factors.
Recent evidence for gross morphological, connectivity
and microstructural changes has now emerged that
warrants further consideration. If cannabis were found
to alter the structural integrity of the brain, then this
may assist us to understand the mechanisms by which
cannabis triggers psychotic symptoms or overt psychosis
in vulnerable individuals.