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Geometry effects on blood separation rate on a rotating disc

Journal Article


Abstract


  • The plasma separation rate is enhanced significantly, as much as 8 times faster for whole blood, by

    simple change of the channel geometry in a rotating disc. It was enhanced in the channels with narrower

    channel widths and larger tilt angles with respect to the radial direction but independent of the channel

    depth or spin direction. A modified Ponder-Nakamura-Kuroda (PNK) theory could nicely fit all of the

    experimental data to a linear line, which data were obtained from spinning discs with various channel

    designs and blood samples with broad hematocrit range. To the best of our knowledge, this is the first

    investigation of geometry effects on the particle separation rate on a rotating disc and it will potentially

    contribute to the further performance enhancement of centrifugal microfluidic devices.

    © 2013 Elsevier B.V. All rights reserved.

UOW Authors


  •   Kim, Tae-Hyeong (external author)
  •   Hwang, Hyundoo (external author)
  •   Gorkin III, Robert
  •   Madou, Marc (external author)
  •   Cho, Yoon-Kyoung (external author)

Publication Date


  • 2013

Citation


  • Kim, T., Hwang, H., Gorkin III, R. A., Madou, M. & Cho, Y. (2013). Geometry effects on blood separation rate on a rotating disc. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 178 (March), 648-655.

Scopus Eid


  • 2-s2.0-84873385255

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/691

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 648

End Page


  • 655

Volume


  • 178

Issue


  • March

Place Of Publication


  • Switzerland

Abstract


  • The plasma separation rate is enhanced significantly, as much as 8 times faster for whole blood, by

    simple change of the channel geometry in a rotating disc. It was enhanced in the channels with narrower

    channel widths and larger tilt angles with respect to the radial direction but independent of the channel

    depth or spin direction. A modified Ponder-Nakamura-Kuroda (PNK) theory could nicely fit all of the

    experimental data to a linear line, which data were obtained from spinning discs with various channel

    designs and blood samples with broad hematocrit range. To the best of our knowledge, this is the first

    investigation of geometry effects on the particle separation rate on a rotating disc and it will potentially

    contribute to the further performance enhancement of centrifugal microfluidic devices.

    © 2013 Elsevier B.V. All rights reserved.

UOW Authors


  •   Kim, Tae-Hyeong (external author)
  •   Hwang, Hyundoo (external author)
  •   Gorkin III, Robert
  •   Madou, Marc (external author)
  •   Cho, Yoon-Kyoung (external author)

Publication Date


  • 2013

Citation


  • Kim, T., Hwang, H., Gorkin III, R. A., Madou, M. & Cho, Y. (2013). Geometry effects on blood separation rate on a rotating disc. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 178 (March), 648-655.

Scopus Eid


  • 2-s2.0-84873385255

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/691

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 648

End Page


  • 655

Volume


  • 178

Issue


  • March

Place Of Publication


  • Switzerland