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Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase

Journal Article


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Abstract


  • Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.

Authors


  •   Yepuri, Rao (external author)
  •   Barraud, Nicolas (external author)
  •   Mohammadi, Nasim Shah. (external author)
  •   Kardak, Bharat G. (external author)
  •   Kjelleberg, Staffan (external author)
  •   Rice, Scott A. (external author)
  •   Kelso, Michael J.

Publication Date


  • 2013

Citation


  • Yepuri, N., Barraud, N., Mohammadi, N. Shah., Kardak, B. G., Kjelleberg, S., Rice, S. A. & Kelso, M. J. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical Communications, 49 (42), 4791-4793.

Scopus Eid


  • 2-s2.0-84877300650

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1687&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/674

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 4791

End Page


  • 4793

Volume


  • 49

Issue


  • 42

Place Of Publication


  • United Kingdom

Abstract


  • Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.

Authors


  •   Yepuri, Rao (external author)
  •   Barraud, Nicolas (external author)
  •   Mohammadi, Nasim Shah. (external author)
  •   Kardak, Bharat G. (external author)
  •   Kjelleberg, Staffan (external author)
  •   Rice, Scott A. (external author)
  •   Kelso, Michael J.

Publication Date


  • 2013

Citation


  • Yepuri, N., Barraud, N., Mohammadi, N. Shah., Kardak, B. G., Kjelleberg, S., Rice, S. A. & Kelso, M. J. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical Communications, 49 (42), 4791-4793.

Scopus Eid


  • 2-s2.0-84877300650

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1687&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/674

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 4791

End Page


  • 4793

Volume


  • 49

Issue


  • 42

Place Of Publication


  • United Kingdom