Objective: To review the literature and discover
which antidepressants are responsible for weight gain and
then to discuss the areas with lack of adequate knowledge.
Method: An electronic search was conducted through
Medline, Pubmed, Cochrane library, and ScienceDirect.
Forty nine empirical researches were identified and reviewed.
Results: Amitriptyline, clomipramine, and mirtazapine have
been associated with more weight gain induction in clinical
studies, but not in animal-based studies. All TCAs have been
reported to cause weight gain except protriptyline. MAOIs
have been associated with weight gain. In SSRI group,
citalopram and ecitalopram induce weight, yet mixed results
exist for paroxetine and fluoxetine. Researches unanimously
reported weight loss effect for bupropion. Some studies
suggest contributing factors in the relationship of
antidepressants with body weight changes including age,
gender, base-line weights and treatment duration. Various
results of different treatment durations have been reported in
some cases but there are not continuous time-dependent
studies for the influences of antidepressants on body weight
Conclusion: More studies are required to discover
underlying mechanisms and the time-dependent effects of
antidepressants on body weight changes.