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Controlled delivery for neuro-bionic devices

Journal Article


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Abstract


  • Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.

UOW Authors


  •   Yue, Zhilian
  •   Moulton, Simon E. (external author)
  •   Cook, Mark J. (external author)
  •   O'Leary, S J (external author)
  •   Wallace, Gordon

Publication Date


  • 2013

Citation


  • Yue, Z., Moulton, S. E., Cook, M., O'Leary, S. & Wallace, G. G. (2013). Controlled delivery for neuro-bionic devices. Advanced Drug Delivery Reviews, 65 (4), 559-569.

Scopus Eid


  • 2-s2.0-84877043675

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1630&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/630

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 559

End Page


  • 569

Volume


  • 65

Issue


  • 4

Place Of Publication


  • Netherlands

Abstract


  • Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.

UOW Authors


  •   Yue, Zhilian
  •   Moulton, Simon E. (external author)
  •   Cook, Mark J. (external author)
  •   O'Leary, S J (external author)
  •   Wallace, Gordon

Publication Date


  • 2013

Citation


  • Yue, Z., Moulton, S. E., Cook, M., O'Leary, S. & Wallace, G. G. (2013). Controlled delivery for neuro-bionic devices. Advanced Drug Delivery Reviews, 65 (4), 559-569.

Scopus Eid


  • 2-s2.0-84877043675

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1630&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/630

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 559

End Page


  • 569

Volume


  • 65

Issue


  • 4

Place Of Publication


  • Netherlands