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Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

Journal Article


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Abstract


  • In order to better understand animal models of Alzheimer's disease, novel phenotyping strategies have been established for transgenic mouse models. In line with this, the current study characterised male APPxPS1 transgenic mice on mixed C57BL/6JxC3H/HeJ background for the first time for social recognition memory, sensorimotor gating, and spatial memory using the cheeseboard test as an alternative to the Morris water maze. Furthermore, locomotion, anxiety, and fear conditioning were evaluated in transgenic and wild type-like animals. APPxPS1 males displayed task-dependent hyperlocomotion and anxiety behaviours and exhibited social recognition memory impairments compared to wild type-like littermates. Spatial learning and memory, fear conditioning, and sensorimotor gating were unaffected in APPxPS1 transgenic mice. In conclusion, this study describes for the first time social recognition memory deficits in male APPxPS1 mice and suggests that spatial learning and memory deficits reported in earlier studies are dependent on the sex and genetic background of the APPxPS1 mouse line used. Furthermore, particular test conditions of anxiety and spatial memory paradigms appear to impact on the behavioural response of this transgenic mouse model for Alzheimer's disease.

Authors


  •   Cheng, D (external author)
  •   Logge, Warren (external author)
  •   Low, Jac Kee. (external author)
  •   Garner, Brett
  •   Karl, Tim (external author)

Publication Date


  • 2013

Citation


  • Cheng, D., Logge, W., Low, J. Kee., Garner, B. & Karl, T. (2013). Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease. Behavioural Brain Research, 245 120-127.

Scopus Eid


  • 2-s2.0-84875244381

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1263&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/246

Number Of Pages


  • 7

Start Page


  • 120

End Page


  • 127

Volume


  • 245

Abstract


  • In order to better understand animal models of Alzheimer's disease, novel phenotyping strategies have been established for transgenic mouse models. In line with this, the current study characterised male APPxPS1 transgenic mice on mixed C57BL/6JxC3H/HeJ background for the first time for social recognition memory, sensorimotor gating, and spatial memory using the cheeseboard test as an alternative to the Morris water maze. Furthermore, locomotion, anxiety, and fear conditioning were evaluated in transgenic and wild type-like animals. APPxPS1 males displayed task-dependent hyperlocomotion and anxiety behaviours and exhibited social recognition memory impairments compared to wild type-like littermates. Spatial learning and memory, fear conditioning, and sensorimotor gating were unaffected in APPxPS1 transgenic mice. In conclusion, this study describes for the first time social recognition memory deficits in male APPxPS1 mice and suggests that spatial learning and memory deficits reported in earlier studies are dependent on the sex and genetic background of the APPxPS1 mouse line used. Furthermore, particular test conditions of anxiety and spatial memory paradigms appear to impact on the behavioural response of this transgenic mouse model for Alzheimer's disease.

Authors


  •   Cheng, D (external author)
  •   Logge, Warren (external author)
  •   Low, Jac Kee. (external author)
  •   Garner, Brett
  •   Karl, Tim (external author)

Publication Date


  • 2013

Citation


  • Cheng, D., Logge, W., Low, J. Kee., Garner, B. & Karl, T. (2013). Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease. Behavioural Brain Research, 245 120-127.

Scopus Eid


  • 2-s2.0-84875244381

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1263&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/246

Number Of Pages


  • 7

Start Page


  • 120

End Page


  • 127

Volume


  • 245