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Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness and memory in cognitively unimpaired individuals and in Alzheimer disease

Journal Article


Abstract


  • Importance β-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer disease. Aβ deposition accelerates gray matter atrophy at early stages of the disease even before objective cognitive impairment is manifested. Identification of at-risk individuals at the presymptomatic stage has become a major research interest because it will allow early therapeutic interventions before irreversible synaptic and neuronal loss occur. We aimed to further characterize the cross-sectional and longitudinal relationship between Aβ deposition, gray matter atrophy, and cognitive impairment.

    Objective To investigate the topographical relationship of Aβ deposition, gray matter atrophy, and memory impairment in asymptomatic individuals with Alzheimer disease pathology as assessed by Pittsburgh compound B positron emission tomography (PiB-PET).

    Design Regional analysis was performed on the cortical surface to relate cortical thickness to PiB retention and episodic memory.

    Setting The Australian Imaging, Biomarkers, and Lifestyle Study of Aging, Austin Hospital, Melbourne, Australia.

    Participants Ninety-three healthy elderly control subjects (NCs) and 40 patients with Alzheimer disease from the Australian Imaging, Biomarkers, and Lifestyle Study of Aging cohort.

    Intervention Participants underwent neuropsychological evaluation as well as magnetic resonance imaging and PiB-PET scans. Fifty-four NCs underwent repeated scans and neuropsychological evaluation 18 and 36 months later.

    Main Outcomes and Measures Correlations between cortical thickness, PiB retention, and episodic memory.

    Results There was a significant reduction in cortical thickness in the precuneus and hippocampus associated with episodic memory impairment in the NC PiB-positive (NC+) group when compared with the NC− group. Cortical thickness was also correlated negatively with neocortical PiB in the NC+ group. Longitudinal analysis showed a faster rate of gray matter (GM) atrophy in the temporal lobe and the hippocampi of the NC+ group. Over time, GM atrophy became more extensive in the NC+ group, especially in the temporal lobe.

Authors


  •   Dore, Vincent (external author)
  •   Villemagne, Victor L. (external author)
  •   Bourgeat, Pierrick (external author)
  •   Fripp, Jurgen (external author)
  •   Dr Oscar Acosta, Oscar (external author)
  •   Chetelat, Gael (external author)
  •   Zhou, Luping
  •   Martins, Ralph N. (external author)
  •   Ellis, Katherine A. (external author)
  •   Masters, Colin L. (external author)
  •   Ames, David (external author)
  •   Salvado, Oliver (external author)
  •   Rowe, Christopher C. (external author)

Publication Date


  • 2013

Citation


  • Dore, V., Villemagne, V. L., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K. A., Masters, C. L., Ames, D., Salvado, O. & Rowe, C. C. (2013). Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70 (7), 903-911.

Scopus Eid


  • 2-s2.0-84880272466

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1500

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 903

End Page


  • 911

Volume


  • 70

Issue


  • 7

Place Of Publication


  • United States

Abstract


  • Importance β-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer disease. Aβ deposition accelerates gray matter atrophy at early stages of the disease even before objective cognitive impairment is manifested. Identification of at-risk individuals at the presymptomatic stage has become a major research interest because it will allow early therapeutic interventions before irreversible synaptic and neuronal loss occur. We aimed to further characterize the cross-sectional and longitudinal relationship between Aβ deposition, gray matter atrophy, and cognitive impairment.

    Objective To investigate the topographical relationship of Aβ deposition, gray matter atrophy, and memory impairment in asymptomatic individuals with Alzheimer disease pathology as assessed by Pittsburgh compound B positron emission tomography (PiB-PET).

    Design Regional analysis was performed on the cortical surface to relate cortical thickness to PiB retention and episodic memory.

    Setting The Australian Imaging, Biomarkers, and Lifestyle Study of Aging, Austin Hospital, Melbourne, Australia.

    Participants Ninety-three healthy elderly control subjects (NCs) and 40 patients with Alzheimer disease from the Australian Imaging, Biomarkers, and Lifestyle Study of Aging cohort.

    Intervention Participants underwent neuropsychological evaluation as well as magnetic resonance imaging and PiB-PET scans. Fifty-four NCs underwent repeated scans and neuropsychological evaluation 18 and 36 months later.

    Main Outcomes and Measures Correlations between cortical thickness, PiB retention, and episodic memory.

    Results There was a significant reduction in cortical thickness in the precuneus and hippocampus associated with episodic memory impairment in the NC PiB-positive (NC+) group when compared with the NC− group. Cortical thickness was also correlated negatively with neocortical PiB in the NC+ group. Longitudinal analysis showed a faster rate of gray matter (GM) atrophy in the temporal lobe and the hippocampi of the NC+ group. Over time, GM atrophy became more extensive in the NC+ group, especially in the temporal lobe.

Authors


  •   Dore, Vincent (external author)
  •   Villemagne, Victor L. (external author)
  •   Bourgeat, Pierrick (external author)
  •   Fripp, Jurgen (external author)
  •   Dr Oscar Acosta, Oscar (external author)
  •   Chetelat, Gael (external author)
  •   Zhou, Luping
  •   Martins, Ralph N. (external author)
  •   Ellis, Katherine A. (external author)
  •   Masters, Colin L. (external author)
  •   Ames, David (external author)
  •   Salvado, Oliver (external author)
  •   Rowe, Christopher C. (external author)

Publication Date


  • 2013

Citation


  • Dore, V., Villemagne, V. L., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K. A., Masters, C. L., Ames, D., Salvado, O. & Rowe, C. C. (2013). Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70 (7), 903-911.

Scopus Eid


  • 2-s2.0-84880272466

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/1500

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 903

End Page


  • 911

Volume


  • 70

Issue


  • 7

Place Of Publication


  • United States