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Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation

Journal Article


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Abstract


  • This article pioneers a study into the influence of the high-Z component of nanoparticles on the efficacy of radioprotection some nanoparticles offer to exposed cells irradiated with X-rays. We reveal a significant decrease in the radioprotection efficacy for cells exposed to CeO2 nanoparticles and irradiated with 10 MV and 150 kVp X-rays. In addition, analysis of the 150 kVp survival curve data indicates a change in radiation quality, becoming more lethal for irradiated cells exposed to CeO2 nanoparticles. We attribute the change in efficacy to an increase in high linear energy transfer Auger electron production at 150 kVp which counterbalances the CeO2 nanoparticle radioprotection capability and locally changes the radiation quality. This study highlights an interesting phenomenon that must be considered if radiation protection drugs for use in radiotherapy are developed based on CeO2 nanoparticles.

Publication Date


  • 2013

Citation


  • Briggs, A., corde, s., Oktaria, S., Brown, R., Rozenfeld, A., Lerch, M., Konstantinov, K. & Tehei, M. (2013). Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation. Nanomedicine, 9 (7), 1098-1105.

Scopus Eid


  • 2-s2.0-84884280491

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1375&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/358

Number Of Pages


  • 7

Start Page


  • 1098

End Page


  • 1105

Volume


  • 9

Issue


  • 7

Abstract


  • This article pioneers a study into the influence of the high-Z component of nanoparticles on the efficacy of radioprotection some nanoparticles offer to exposed cells irradiated with X-rays. We reveal a significant decrease in the radioprotection efficacy for cells exposed to CeO2 nanoparticles and irradiated with 10 MV and 150 kVp X-rays. In addition, analysis of the 150 kVp survival curve data indicates a change in radiation quality, becoming more lethal for irradiated cells exposed to CeO2 nanoparticles. We attribute the change in efficacy to an increase in high linear energy transfer Auger electron production at 150 kVp which counterbalances the CeO2 nanoparticle radioprotection capability and locally changes the radiation quality. This study highlights an interesting phenomenon that must be considered if radiation protection drugs for use in radiotherapy are developed based on CeO2 nanoparticles.

Publication Date


  • 2013

Citation


  • Briggs, A., corde, s., Oktaria, S., Brown, R., Rozenfeld, A., Lerch, M., Konstantinov, K. & Tehei, M. (2013). Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation. Nanomedicine, 9 (7), 1098-1105.

Scopus Eid


  • 2-s2.0-84884280491

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1375&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/358

Number Of Pages


  • 7

Start Page


  • 1098

End Page


  • 1105

Volume


  • 9

Issue


  • 7