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Self-reported side effects of breast cancer treatment: a cross-sectional study of incidence, associations, and the influence of exercise

Journal Article


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Abstract


  • Purpose

    Side effects as a result of breast cancer treatment may have a lasting detrimental impact on quality of life. Exercise has been shown to be an effective intervention in post-treatment care. This study aimed to gain a better understanding of breast cancer treatment-related side effects through identifying potential patient characteristic associations, including current levels of exercise.

    Methods

    Four hundred and thirty-two breast cancer patients completed an online survey covering their treatment and demographic background, current exercise levels, and self-reported treatment side effects. Side effects were considered in a binary logistic regression against age, surgery, currently undergoing treatment, and exercise levels to ascertain significant relationships (p < 0.05) and associative values (Odds Ratio).

    Results

    Lumpectomy patients were less likely to report aching muscles (OR 0.61, 95 % CI 0.39–0.96), hot flushes (OR 0.60, 95 % CI 0.38–0.96), and weight gain (OR 0.59, 95 % CI 0.38–0.92) than mastectomy patients. Women currently undergoing treatment were more likely to report hot flushes (OR 3.77, 95 % CI 2.34–6.08), aching muscles (OR 1.62, 95 % CI 1.02–2.57), and weight gain (OR 1.89, 95 % CI 1.19–2.99) than women finished treatment. Sedentary women were more likely to experience shoulder limitations (OR 1.77, 95 % CI 1.14–2.77), muscular chest wall pain (OR 1.69, 95 % CI 1.07–2.65), weight gain (OR 2.29, 95 % CI 1.44–3.64), lymphedema (OR 1.68, 95 % CI 1.04–2.71), and breathlessness (OR 2.30 95 % CI 1.35–3.92) than their physically active counterparts.

    Conclusions

    Patient characteristics may inform interventions to improve care post-breast cancer treatment. Sufficient levels of exercise were consistently associated fewer side effects and should be encouraged.

Publication Date


  • 2013

Citation


  • Gho, S., Steele, J. R., Jones, S. C. & Munro, B. J. (2013). Self-reported side effects of breast cancer treatment: a cross-sectional study of incidence, associations, and the influence of exercise. Cancer Causes and Control, 24 (3), 517-528.

Scopus Eid


  • 2-s2.0-84878890994

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1834&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/821

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 517

End Page


  • 528

Volume


  • 24

Issue


  • 3

Place Of Publication


  • Netherlands

Abstract


  • Purpose

    Side effects as a result of breast cancer treatment may have a lasting detrimental impact on quality of life. Exercise has been shown to be an effective intervention in post-treatment care. This study aimed to gain a better understanding of breast cancer treatment-related side effects through identifying potential patient characteristic associations, including current levels of exercise.

    Methods

    Four hundred and thirty-two breast cancer patients completed an online survey covering their treatment and demographic background, current exercise levels, and self-reported treatment side effects. Side effects were considered in a binary logistic regression against age, surgery, currently undergoing treatment, and exercise levels to ascertain significant relationships (p < 0.05) and associative values (Odds Ratio).

    Results

    Lumpectomy patients were less likely to report aching muscles (OR 0.61, 95 % CI 0.39–0.96), hot flushes (OR 0.60, 95 % CI 0.38–0.96), and weight gain (OR 0.59, 95 % CI 0.38–0.92) than mastectomy patients. Women currently undergoing treatment were more likely to report hot flushes (OR 3.77, 95 % CI 2.34–6.08), aching muscles (OR 1.62, 95 % CI 1.02–2.57), and weight gain (OR 1.89, 95 % CI 1.19–2.99) than women finished treatment. Sedentary women were more likely to experience shoulder limitations (OR 1.77, 95 % CI 1.14–2.77), muscular chest wall pain (OR 1.69, 95 % CI 1.07–2.65), weight gain (OR 2.29, 95 % CI 1.44–3.64), lymphedema (OR 1.68, 95 % CI 1.04–2.71), and breathlessness (OR 2.30 95 % CI 1.35–3.92) than their physically active counterparts.

    Conclusions

    Patient characteristics may inform interventions to improve care post-breast cancer treatment. Sufficient levels of exercise were consistently associated fewer side effects and should be encouraged.

Publication Date


  • 2013

Citation


  • Gho, S., Steele, J. R., Jones, S. C. & Munro, B. J. (2013). Self-reported side effects of breast cancer treatment: a cross-sectional study of incidence, associations, and the influence of exercise. Cancer Causes and Control, 24 (3), 517-528.

Scopus Eid


  • 2-s2.0-84878890994

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1834&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/821

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 517

End Page


  • 528

Volume


  • 24

Issue


  • 3

Place Of Publication


  • Netherlands