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Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester

Journal Article


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Abstract


  • CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL).

    HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase.

    DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally.

    SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a clinical research suite.

    OUTCOME MEASURES: Plasma concentrations of lipids, triglyceride-rich lipoproteins, lipoprotein lipase mass, estradiol, steroid hormone binding globulin, insulin, glucose, leptin, and adiponectin were determined. RESULTS: Obese women commenced pregnancy with higher plasma triglyceride, reached the same maximum, and then returned to higher postnatal levels than normal-weight women. Estradiol response to pregnancy (trimester 1-3 incremental area under the curve) was positively associated with plasma triglyceride response (r(2) adjusted 25%, P <.001). In the third trimester, the proportion of small, dense LDL was 2-fold higher in obese women than normal-weight women [mean (SD) 40.7 (18.8) vs 21.9 (10.9)%, P =.014], and 35% of obese, 14% of overweight, and none of the normal-weight women displayed an atherogenic LDL subfraction phenotype. The small, dense LDL mass response to pregnancy was inversely associated with adiponectin response (17%, P =.013).

    CONCLUSIONS: Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome.

Authors


  •   Meyer, Barbara J.
  •   Stewart, Frances M. (external author)
  •   Brown, Elizabeth A. (external author)
  •   Cooney, Josephine (external author)
  •   Nilsson, Solveig (external author)
  •   Olivecrona, Gunilla (external author)
  •   Ramsay, Jane E. (external author)
  •   Griffin, Bruce A. (external author)
  •   Caslake, Muriel (external author)
  •   Freeman, Dilys J. (external author)

Publication Date


  • 2013

Citation


  • Meyer, B. J., Stewart, F. M., Brown, E. A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J. E., Griffin, B. A., Caslake, M. J. & Freeman, D. J. (2013). Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98 (2), 643-652.

Scopus Eid


  • 2-s2.0-84873646034

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1943&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/928

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 643

End Page


  • 652

Volume


  • 98

Issue


  • 2

Place Of Publication


  • United States

Abstract


  • CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL).

    HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase.

    DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally.

    SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a clinical research suite.

    OUTCOME MEASURES: Plasma concentrations of lipids, triglyceride-rich lipoproteins, lipoprotein lipase mass, estradiol, steroid hormone binding globulin, insulin, glucose, leptin, and adiponectin were determined. RESULTS: Obese women commenced pregnancy with higher plasma triglyceride, reached the same maximum, and then returned to higher postnatal levels than normal-weight women. Estradiol response to pregnancy (trimester 1-3 incremental area under the curve) was positively associated with plasma triglyceride response (r(2) adjusted 25%, P <.001). In the third trimester, the proportion of small, dense LDL was 2-fold higher in obese women than normal-weight women [mean (SD) 40.7 (18.8) vs 21.9 (10.9)%, P =.014], and 35% of obese, 14% of overweight, and none of the normal-weight women displayed an atherogenic LDL subfraction phenotype. The small, dense LDL mass response to pregnancy was inversely associated with adiponectin response (17%, P =.013).

    CONCLUSIONS: Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome.

Authors


  •   Meyer, Barbara J.
  •   Stewart, Frances M. (external author)
  •   Brown, Elizabeth A. (external author)
  •   Cooney, Josephine (external author)
  •   Nilsson, Solveig (external author)
  •   Olivecrona, Gunilla (external author)
  •   Ramsay, Jane E. (external author)
  •   Griffin, Bruce A. (external author)
  •   Caslake, Muriel (external author)
  •   Freeman, Dilys J. (external author)

Publication Date


  • 2013

Citation


  • Meyer, B. J., Stewart, F. M., Brown, E. A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J. E., Griffin, B. A., Caslake, M. J. & Freeman, D. J. (2013). Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98 (2), 643-652.

Scopus Eid


  • 2-s2.0-84873646034

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1943&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/928

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 643

End Page


  • 652

Volume


  • 98

Issue


  • 2

Place Of Publication


  • United States