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Alteration to hippocampal shape in cannabis users with and without schizophrenia

Journal Article


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Abstract


  • Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.

UOW Authors


  •   Solowij, Nadia
  •   Walterfang, Mark (external author)
  •   Lubman, Daniel I. (external author)
  •   Whittle, Sarah (external author)
  •   Lorenzetti, Valentina (external author)
  •   Styner, Martin (external author)
  •   Velakoulis, Dennis (external author)
  •   Pantelis, Christos (external author)
  •   Yuecel, Murat (external author)

Publication Date


  • 2013

Citation


  • Solowij, N., Walterfang, M., Lubman, D. I., Whittle, S., Lorenzetti, V., Styner, M., Velakoulis, D., Pantelis, C. & Yuecel, M. (2013). Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research, 143 (1), 179-184.

Scopus Eid


  • 2-s2.0-84871933160

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1001&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/2

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 179

End Page


  • 184

Volume


  • 143

Issue


  • 1

Place Of Publication


  • Netherlands

Abstract


  • Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.

UOW Authors


  •   Solowij, Nadia
  •   Walterfang, Mark (external author)
  •   Lubman, Daniel I. (external author)
  •   Whittle, Sarah (external author)
  •   Lorenzetti, Valentina (external author)
  •   Styner, Martin (external author)
  •   Velakoulis, Dennis (external author)
  •   Pantelis, Christos (external author)
  •   Yuecel, Murat (external author)

Publication Date


  • 2013

Citation


  • Solowij, N., Walterfang, M., Lubman, D. I., Whittle, S., Lorenzetti, V., Styner, M., Velakoulis, D., Pantelis, C. & Yuecel, M. (2013). Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research, 143 (1), 179-184.

Scopus Eid


  • 2-s2.0-84871933160

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1001&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/2

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 179

End Page


  • 184

Volume


  • 143

Issue


  • 1

Place Of Publication


  • Netherlands