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Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

Journal Article


Abstract


  • Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.

Authors


  •   Linley, John (external author)
  •   Rosen, Kirstin (external author)
  •   Ooi, Lezanne
  •   Gamper, Nikita (external author)

Publication Date


  • 2010

Citation


  • Linley, J. E., Rosen, K., Ooi, L. & Gamper, N. (2010). Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pfluegers Archiv: European journal of physiology, 459 (5), 657-669.

Scopus Eid


  • 2-s2.0-77950921542

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4661

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 657

End Page


  • 669

Volume


  • 459

Issue


  • 5

Place Of Publication


  • Germany

Abstract


  • Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.

Authors


  •   Linley, John (external author)
  •   Rosen, Kirstin (external author)
  •   Ooi, Lezanne
  •   Gamper, Nikita (external author)

Publication Date


  • 2010

Citation


  • Linley, J. E., Rosen, K., Ooi, L. & Gamper, N. (2010). Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pfluegers Archiv: European journal of physiology, 459 (5), 657-669.

Scopus Eid


  • 2-s2.0-77950921542

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4661

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 657

End Page


  • 669

Volume


  • 459

Issue


  • 5

Place Of Publication


  • Germany