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Chromatin switching and transcriptional regulation in disease

Journal Article


Abstract


  • Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis. Understanding the molecular mechanisms responsible for these changes in gene expression is a major goal, in order to identify novel therapeutic targets.

Authors


Publication Date


  • 2008

Citation


  • Ooi, L. & Wood, I. C. (2008). Chromatin switching and transcriptional regulation in disease. Biochemical Society Transactions, 36 (4), 599-602.

Scopus Eid


  • 2-s2.0-49349117189

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4651

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 599

End Page


  • 602

Volume


  • 36

Issue


  • 4

Place Of Publication


  • United Kingdom

Abstract


  • Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis. Understanding the molecular mechanisms responsible for these changes in gene expression is a major goal, in order to identify novel therapeutic targets.

Authors


Publication Date


  • 2008

Citation


  • Ooi, L. & Wood, I. C. (2008). Chromatin switching and transcriptional regulation in disease. Biochemical Society Transactions, 36 (4), 599-602.

Scopus Eid


  • 2-s2.0-49349117189

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4651

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 599

End Page


  • 602

Volume


  • 36

Issue


  • 4

Place Of Publication


  • United Kingdom