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Extracellular chaperones and proteostasis

Journal Article


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Abstract


  • There is a family of currently untreatable serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited but has significantly advanced with the discovery of a small but growing family of constitutively secreted extracellular chaperones (ECs). The available evidence strongly suggests that these chaperones act as both sensors and disposal-mediators of misfolded proteins in extracellular fluids, thereby normally protecting us from disease pathologies. It is critically important to further increase our understanding of the mechanisms that operate to effect extracellular proteostasis, as this will be essential knowledge upon which to base the development of effective therapies for some of the world's most debilitating, costly and intractable diseases.

Publication Date


  • 2013

Citation


  • Wyatt, A. R., Yerbury, J. J., Ecroyd, H. & Wilson, M. R. (2013). Extracellular chaperones and proteostasis. Annual Review of Biochemistry, 82 295-322.

Scopus Eid


  • 2-s2.0-84878916720

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1937&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/922

Has Global Citation Frequency


Number Of Pages


  • 27

Start Page


  • 295

End Page


  • 322

Volume


  • 82

Place Of Publication


  • United States

Abstract


  • There is a family of currently untreatable serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited but has significantly advanced with the discovery of a small but growing family of constitutively secreted extracellular chaperones (ECs). The available evidence strongly suggests that these chaperones act as both sensors and disposal-mediators of misfolded proteins in extracellular fluids, thereby normally protecting us from disease pathologies. It is critically important to further increase our understanding of the mechanisms that operate to effect extracellular proteostasis, as this will be essential knowledge upon which to base the development of effective therapies for some of the world's most debilitating, costly and intractable diseases.

Publication Date


  • 2013

Citation


  • Wyatt, A. R., Yerbury, J. J., Ecroyd, H. & Wilson, M. R. (2013). Extracellular chaperones and proteostasis. Annual Review of Biochemistry, 82 295-322.

Scopus Eid


  • 2-s2.0-84878916720

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1937&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/922

Has Global Citation Frequency


Number Of Pages


  • 27

Start Page


  • 295

End Page


  • 322

Volume


  • 82

Place Of Publication


  • United States