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Resting state EEG and symptoms of ADHD

Journal Article


Abstract


  • Centre for Psychophysics, Psychophysiology, and Psychopharmacology,

    University of Wollongong, Wollongong, Australia

    Brain & Behaviour Research Institute, University of Wollongong,

    Wollongong, Australia

    School of Psychology, University of Wollongong, Wollongong, Australia

    We regard resting-state EEG as reflecting the dynamic potential of

    the brain's current functional state — it provides the substrate of all

    cognitive and perceptual processing. Our research program on the

    electrophysiology of AD/HDhas been ongoing for some 20 years, andwe

    have examined resting-state EEG power and coherence, aswell as ERPs,

    in AD/HD patients, ranging across children, adolescents, and adults. This

    presentation covers some of those studies, concentrating on restingstate

    EEG power and coherence in children. In relation to power studies,

    it iswell-established that childrenwith AD/HD showglobally-enhanced

    absolute delta and theta power, globally-reduced absolute alpha and

    beta power, and elevated theta/beta ratio. In relative power terms,

    globally elevated theta and reduced alpha and beta are observed, with

    fronto-central reductions in delta. All these anomalies are more

    extensive in children with the combined type of AD/HD, compared

    with the inattentive type, so these anomalies clearly relate to some

    extent with hyperactivity. In separate studies we have found significant

    positive correlations of scores on the Connors' Inattention scale with

    global absolute theta and frontal relative theta, and negative correlations

    with absolute gamma power. Further, scores on the Connors'

    Hyperactivity–Impulsivity scale have been correlated positively with

    the theta/beta ratio. That is, deviant EEG power profiles have been

    positively associated with the dominant symptoms of AD/HD. With

    resting-state EEG coherence, AD/HD is associated with elevated intrahemispheric

    coherences at shorter inter-electrode distances in theta,

    and reduced lateral differences in theta and alpha. At longer interelectrode

    distances, patients have reduced intra-hemispheric alpha

    coherences. With inter-hemispheric electrode pairs, children with AD/

    HD have frontal coherences elevated in delta and theta, and reduced

    in alpha. Temporal coherence is reduced in alpha, and central/parietal/

    occipital coherence is enhanced in theta. In relation to EEG coherence

    and symptoms,we have reported that reduced left-lateralised coherences

    across delta, alpha, beta, and gamma bands correlate negatively with

    Inattention scores, while reduced frontal inter-hemispheric coherences

    correlate negatively with hyperactivity–impulsivity scores. These negative

    correlations between anomalous coherences and symptoms suggest

    the involvement of compensatory processes. Future studies may provide

    more understanding of the brain dysfunctions involved in AD/HD by

    pursuing such EEG anomaly/symptom linkages across a wide age-range.

Publication Date


  • 2012

Citation


  • Barry, R. J. & Clarke, A. R. (2012). Resting state EEG and symptoms of ADHD. International Journal of Psychophysiology, 85 (3), 294-294.

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3058

Number Of Pages


  • 0

Start Page


  • 294

End Page


  • 294

Volume


  • 85

Issue


  • 3

Abstract


  • Centre for Psychophysics, Psychophysiology, and Psychopharmacology,

    University of Wollongong, Wollongong, Australia

    Brain & Behaviour Research Institute, University of Wollongong,

    Wollongong, Australia

    School of Psychology, University of Wollongong, Wollongong, Australia

    We regard resting-state EEG as reflecting the dynamic potential of

    the brain's current functional state — it provides the substrate of all

    cognitive and perceptual processing. Our research program on the

    electrophysiology of AD/HDhas been ongoing for some 20 years, andwe

    have examined resting-state EEG power and coherence, aswell as ERPs,

    in AD/HD patients, ranging across children, adolescents, and adults. This

    presentation covers some of those studies, concentrating on restingstate

    EEG power and coherence in children. In relation to power studies,

    it iswell-established that childrenwith AD/HD showglobally-enhanced

    absolute delta and theta power, globally-reduced absolute alpha and

    beta power, and elevated theta/beta ratio. In relative power terms,

    globally elevated theta and reduced alpha and beta are observed, with

    fronto-central reductions in delta. All these anomalies are more

    extensive in children with the combined type of AD/HD, compared

    with the inattentive type, so these anomalies clearly relate to some

    extent with hyperactivity. In separate studies we have found significant

    positive correlations of scores on the Connors' Inattention scale with

    global absolute theta and frontal relative theta, and negative correlations

    with absolute gamma power. Further, scores on the Connors'

    Hyperactivity–Impulsivity scale have been correlated positively with

    the theta/beta ratio. That is, deviant EEG power profiles have been

    positively associated with the dominant symptoms of AD/HD. With

    resting-state EEG coherence, AD/HD is associated with elevated intrahemispheric

    coherences at shorter inter-electrode distances in theta,

    and reduced lateral differences in theta and alpha. At longer interelectrode

    distances, patients have reduced intra-hemispheric alpha

    coherences. With inter-hemispheric electrode pairs, children with AD/

    HD have frontal coherences elevated in delta and theta, and reduced

    in alpha. Temporal coherence is reduced in alpha, and central/parietal/

    occipital coherence is enhanced in theta. In relation to EEG coherence

    and symptoms,we have reported that reduced left-lateralised coherences

    across delta, alpha, beta, and gamma bands correlate negatively with

    Inattention scores, while reduced frontal inter-hemispheric coherences

    correlate negatively with hyperactivity–impulsivity scores. These negative

    correlations between anomalous coherences and symptoms suggest

    the involvement of compensatory processes. Future studies may provide

    more understanding of the brain dysfunctions involved in AD/HD by

    pursuing such EEG anomaly/symptom linkages across a wide age-range.

Publication Date


  • 2012

Citation


  • Barry, R. J. & Clarke, A. R. (2012). Resting state EEG and symptoms of ADHD. International Journal of Psychophysiology, 85 (3), 294-294.

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3058

Number Of Pages


  • 0

Start Page


  • 294

End Page


  • 294

Volume


  • 85

Issue


  • 3