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Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway

Journal Article


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Abstract


  • Dendritic spine morphology is modulated by protein kinase p38, a mitogen-activated protein (MAPK), in the hippocampus. Protein p38MAPK is a substrate of wip1, a protein phosphatase. The role of wip1 in the central nervous system (CNS) has never been explored. Here, we report a novel function of wip1 in dendritic spine morphology and memory processes. Wip1 deficiency decreases dendritic spine size and density in pyramidal neurons of the hippocampal CA1 region. Simultaneously, impairments in object recognition tasks and contextual memory occur in wip1 deficient mice, but are reversed in wip1/p38 double mutant mice. Thus, our findings demonstrate that wip1 modulates dendritic morphology and memory processes through the p38MAPK signaling pathway. In addition to the well-characterized role of the wip1/p38MAPK in cell death and differentiation, we revealed the novel contribution of wip1 to cognition and dendritic spine morphology, which may suggest new approaches to treating neurodegenerative disorders.

Authors


  •   Fernandez-Enright, Francesca E.
  •   Soon, I (external author)
  •   Li, Zeng (external author)
  •   Kuan, T (external author)
  •   Min, D (external author)
  •   Wong, Esther Sook-Miin. (external author)
  •   Demidov, O (external author)
  •   Paterson, Malcolm C. (external author)
  •   Dawe, G (external author)
  •   Bulavin, D (external author)
  •   Xiao, Zhitao (external author)

Publication Date


  • 2012

Citation


  • Fernandez, F., Soon, I., Li, Z., Kuan, T. Chee., Min, D. Hong., Wong, E. Sook-Miin., Demidov, O. N., Paterson, M. C., Dawe, G., Bulavin, D. V. & Xiao, Z. (2012). Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway. Cell Adhesion and Migration, 6 (4), 333-343.

Scopus Eid


  • 2-s2.0-84867267566

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4104&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3052

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 333

End Page


  • 343

Volume


  • 6

Issue


  • 4

Place Of Publication


  • United States

Abstract


  • Dendritic spine morphology is modulated by protein kinase p38, a mitogen-activated protein (MAPK), in the hippocampus. Protein p38MAPK is a substrate of wip1, a protein phosphatase. The role of wip1 in the central nervous system (CNS) has never been explored. Here, we report a novel function of wip1 in dendritic spine morphology and memory processes. Wip1 deficiency decreases dendritic spine size and density in pyramidal neurons of the hippocampal CA1 region. Simultaneously, impairments in object recognition tasks and contextual memory occur in wip1 deficient mice, but are reversed in wip1/p38 double mutant mice. Thus, our findings demonstrate that wip1 modulates dendritic morphology and memory processes through the p38MAPK signaling pathway. In addition to the well-characterized role of the wip1/p38MAPK in cell death and differentiation, we revealed the novel contribution of wip1 to cognition and dendritic spine morphology, which may suggest new approaches to treating neurodegenerative disorders.

Authors


  •   Fernandez-Enright, Francesca E.
  •   Soon, I (external author)
  •   Li, Zeng (external author)
  •   Kuan, T (external author)
  •   Min, D (external author)
  •   Wong, Esther Sook-Miin. (external author)
  •   Demidov, O (external author)
  •   Paterson, Malcolm C. (external author)
  •   Dawe, G (external author)
  •   Bulavin, D (external author)
  •   Xiao, Zhitao (external author)

Publication Date


  • 2012

Citation


  • Fernandez, F., Soon, I., Li, Z., Kuan, T. Chee., Min, D. Hong., Wong, E. Sook-Miin., Demidov, O. N., Paterson, M. C., Dawe, G., Bulavin, D. V. & Xiao, Z. (2012). Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway. Cell Adhesion and Migration, 6 (4), 333-343.

Scopus Eid


  • 2-s2.0-84867267566

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4104&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3052

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 333

End Page


  • 343

Volume


  • 6

Issue


  • 4

Place Of Publication


  • United States