Skip to main content

In silico nanodosimetry: New insights into nontargeted biological responses to radiation

Journal Article


Download full-text (Open Access)

Abstract


  • The long-held view that radiation-induced biological damage must be initiated in the cell nucleus, either on or near DNA itself, is

    being confronted by mounting evidence to suggest otherwise. While the efficacy of cell death may be determined by radiation

    damage to nuclear DNA, a plethora of less deterministic biological responses has been observed when DNA is not targeted.

    These so-called nontargeted responses cannot be understood in the framework of DNA-centric radiobiological models; what is

    needed are new physically motivated models that address the damage-sensing signalling pathways triggered by the production

    of reactive free radicals. To this end, we have conducted a series of in silico experiments aimed at elucidating the underlying

    physical processes responsible for nontargeted biological responses to radiation. Our simulation studies implement new results

    on very low-energy electromagnetic interactions in liquid water (applicable down to nanoscales) and we also consider a realistic

    simulation of extranuclear microbeam irradiation of a cell. Our results support the idea that organelles with important functional

    roles, such as mitochondria and lysosomes, as well as membranes, are viable targets for ionizations and excitations, and their

    chemical composition and density are critical to determining the free radical yield and ensuing biological responses.

Authors


  •   Kuncic, Zdenka (external author)
  •   Byrne, Hilary L. (external author)
  •   McNamara, Aimee L. (external author)
  •   Guatelli, Susanna
  •   Domanova, Westa (external author)
  •   Incerti, Sebastian (external author)

Publication Date


  • 2012

Citation


  • Kuncic, Z., Byrne, H. L., McNamara, A. L., Guatelli, S., Domanova, W. & Incerti, S. (2012). In silico nanodosimetry: New insights into nontargeted biological responses to radiation. Computational and Mathematical Methods in Medicine, 2012 1-9.

Scopus Eid


  • 2-s2.0-84863708518

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1468&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/463

Number Of Pages


  • 8

Start Page


  • 1

End Page


  • 9

Volume


  • 2012

Abstract


  • The long-held view that radiation-induced biological damage must be initiated in the cell nucleus, either on or near DNA itself, is

    being confronted by mounting evidence to suggest otherwise. While the efficacy of cell death may be determined by radiation

    damage to nuclear DNA, a plethora of less deterministic biological responses has been observed when DNA is not targeted.

    These so-called nontargeted responses cannot be understood in the framework of DNA-centric radiobiological models; what is

    needed are new physically motivated models that address the damage-sensing signalling pathways triggered by the production

    of reactive free radicals. To this end, we have conducted a series of in silico experiments aimed at elucidating the underlying

    physical processes responsible for nontargeted biological responses to radiation. Our simulation studies implement new results

    on very low-energy electromagnetic interactions in liquid water (applicable down to nanoscales) and we also consider a realistic

    simulation of extranuclear microbeam irradiation of a cell. Our results support the idea that organelles with important functional

    roles, such as mitochondria and lysosomes, as well as membranes, are viable targets for ionizations and excitations, and their

    chemical composition and density are critical to determining the free radical yield and ensuing biological responses.

Authors


  •   Kuncic, Zdenka (external author)
  •   Byrne, Hilary L. (external author)
  •   McNamara, Aimee L. (external author)
  •   Guatelli, Susanna
  •   Domanova, Westa (external author)
  •   Incerti, Sebastian (external author)

Publication Date


  • 2012

Citation


  • Kuncic, Z., Byrne, H. L., McNamara, A. L., Guatelli, S., Domanova, W. & Incerti, S. (2012). In silico nanodosimetry: New insights into nontargeted biological responses to radiation. Computational and Mathematical Methods in Medicine, 2012 1-9.

Scopus Eid


  • 2-s2.0-84863708518

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1468&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/463

Number Of Pages


  • 8

Start Page


  • 1

End Page


  • 9

Volume


  • 2012