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Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale

Journal Article


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Abstract


  • The essential oil of the leaves Solanium spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. (E)-Phytol (48.10%), n-hexadecanoic acid (7.34%), beta-selinene (3.67%), alpha-selinene (2.74%), octadecanoic acid (2.12%) and hexahydrofarnesyl acetone (2.00%) were the major components of this oil. The antioxidant activity of the essential oil was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. The oil exhibited week antioxidant activity with an IC50 of 41.89 mg/mL. The essential oil showed significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with MIC values of 43.0 microg/mL and 21.5 microg/mL, respectively. It also showed significant cytotoxicity against KB (oral cancer), MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 26.42, 19.69, and 24.02 microg/mL, respectively.

UOW Authors


  •   Keawsa-Ard, Sukanya (external author)
  •   Liawruangrath, Boonsom (external author)
  •   Liawruangrath, Saisunee (external author)
  •   Teerawutgulrag, Aphiwat (external author)
  •   Pyne, Stephen

Publication Date


  • 2012

Citation


  • Keawsa-Ard, S., Liawruangrath, B., Liawruangrath, S., Teerawutgulrag, A. & Pyne, S. G. (2012). Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale. Natural Product Communications: an international journal for communications and reviews, 7 (7), 955-958.

Scopus Eid


  • 2-s2.0-84864700550

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1185&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/186

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 955

End Page


  • 958

Volume


  • 7

Issue


  • 7

Place Of Publication


  • United States

Abstract


  • The essential oil of the leaves Solanium spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. (E)-Phytol (48.10%), n-hexadecanoic acid (7.34%), beta-selinene (3.67%), alpha-selinene (2.74%), octadecanoic acid (2.12%) and hexahydrofarnesyl acetone (2.00%) were the major components of this oil. The antioxidant activity of the essential oil was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. The oil exhibited week antioxidant activity with an IC50 of 41.89 mg/mL. The essential oil showed significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with MIC values of 43.0 microg/mL and 21.5 microg/mL, respectively. It also showed significant cytotoxicity against KB (oral cancer), MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 26.42, 19.69, and 24.02 microg/mL, respectively.

UOW Authors


  •   Keawsa-Ard, Sukanya (external author)
  •   Liawruangrath, Boonsom (external author)
  •   Liawruangrath, Saisunee (external author)
  •   Teerawutgulrag, Aphiwat (external author)
  •   Pyne, Stephen

Publication Date


  • 2012

Citation


  • Keawsa-Ard, S., Liawruangrath, B., Liawruangrath, S., Teerawutgulrag, A. & Pyne, S. G. (2012). Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale. Natural Product Communications: an international journal for communications and reviews, 7 (7), 955-958.

Scopus Eid


  • 2-s2.0-84864700550

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1185&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/186

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 955

End Page


  • 958

Volume


  • 7

Issue


  • 7

Place Of Publication


  • United States