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The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

Journal Article


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Abstract


  • The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).

UOW Authors


  •   Khamsan, Sorachai (external author)
  •   Liawruangrath, Saisunee (external author)
  •   Teerawutkulrag, Aphiwat (external author)
  •   Pyne, Stephen
  •   Garson, Mary J. (external author)
  •   Liawruangrath, Boonsom (external author)

Publication Date


  • 2012

Citation


  • Khamsan, S., Liawruangrath, S., Teerawutkulrag, A., Pyne, S. G., Garson, M. J. & Liawruangrath, B. (2012). The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. Acta Pharmaceutica, 62 (2), 181-190.

Scopus Eid


  • 2-s2.0-84863450704

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8069&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4726

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 181

End Page


  • 190

Volume


  • 62

Issue


  • 2

Place Of Publication


  • Croatia

Abstract


  • The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).

UOW Authors


  •   Khamsan, Sorachai (external author)
  •   Liawruangrath, Saisunee (external author)
  •   Teerawutkulrag, Aphiwat (external author)
  •   Pyne, Stephen
  •   Garson, Mary J. (external author)
  •   Liawruangrath, Boonsom (external author)

Publication Date


  • 2012

Citation


  • Khamsan, S., Liawruangrath, S., Teerawutkulrag, A., Pyne, S. G., Garson, M. J. & Liawruangrath, B. (2012). The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. Acta Pharmaceutica, 62 (2), 181-190.

Scopus Eid


  • 2-s2.0-84863450704

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8069&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4726

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 181

End Page


  • 190

Volume


  • 62

Issue


  • 2

Place Of Publication


  • Croatia