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Chromatin crosstalk in development and disease: lessons from REST

Journal Article


Abstract


  • Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression. Recent studies have shown that a single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation. Research into the function of REST and its corepressors has provided novel insight into how chromatin-modifying proteins cooperate, and how alterations in this function cause disease. These mechanisms will be relevant to the combinatorial functioning of modular transcriptional regulators that work together to regulate a common promoter; they should also identify targets for potential therapies for a range of human diseases.

Authors


Publication Date


  • 2007

Citation


  • Ooi, L. & Wood, I. (2007). Chromatin crosstalk in development and disease: lessons from REST. Nature Reviews: Genetics, 8 (7), 544-554.

Scopus Eid


  • 2-s2.0-34250767817

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4648

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 544

End Page


  • 554

Volume


  • 8

Issue


  • 7

Place Of Publication


  • United Kingdom

Abstract


  • Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression. Recent studies have shown that a single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation. Research into the function of REST and its corepressors has provided novel insight into how chromatin-modifying proteins cooperate, and how alterations in this function cause disease. These mechanisms will be relevant to the combinatorial functioning of modular transcriptional regulators that work together to regulate a common promoter; they should also identify targets for potential therapies for a range of human diseases.

Authors


Publication Date


  • 2007

Citation


  • Ooi, L. & Wood, I. (2007). Chromatin crosstalk in development and disease: lessons from REST. Nature Reviews: Genetics, 8 (7), 544-554.

Scopus Eid


  • 2-s2.0-34250767817

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4648

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 544

End Page


  • 554

Volume


  • 8

Issue


  • 7

Place Of Publication


  • United Kingdom