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Is Seladin-1 really a selective Alzheimer's disease indicator?

Journal Article


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Abstract


  • Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.

Authors


  •   Sharpe, L J. (external author)
  •   Wong, Jenny (external author)
  •   Garner, Brett
  •   Halliday, Glenda M. (external author)
  •   Brown, Andrew J. (external author)

Publication Date


  • 2012

Citation


  • Sharpe, L. J., Wong, J., Garner, B., Halliday, G. M. & Brown, A. J. (2012). Is Seladin-1 really a selective Alzheimer's disease indicator?. Journal of Alzheimer's Disease, 30 (1), 35-39.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1334&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/322

Number Of Pages


  • 4

Start Page


  • 35

End Page


  • 39

Volume


  • 30

Issue


  • 1

Abstract


  • Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.

Authors


  •   Sharpe, L J. (external author)
  •   Wong, Jenny (external author)
  •   Garner, Brett
  •   Halliday, Glenda M. (external author)
  •   Brown, Andrew J. (external author)

Publication Date


  • 2012

Citation


  • Sharpe, L. J., Wong, J., Garner, B., Halliday, G. M. & Brown, A. J. (2012). Is Seladin-1 really a selective Alzheimer's disease indicator?. Journal of Alzheimer's Disease, 30 (1), 35-39.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1334&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/322

Number Of Pages


  • 4

Start Page


  • 35

End Page


  • 39

Volume


  • 30

Issue


  • 1