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The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia

Journal Article


Abstract


  • Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative Syndrome Scale (PANSS).

    Results:We showedthat theDBH50-Ins/Del deletion (Del) allelic and genotypic frequencieswere significantly lower in controls than first-episode of schizophrenics (FES) (both p < 0.001), but controlswere not different from chronic schizophrenics. Furthermore, the PANSS positive symptom and total scores were significantly higher in FES with the Del/Del genotype than those with Ins/Del and Ins/Ins genotypes (all p < 0.05). Conclusions: The DBH50-Ins/Del polymorphism may play a role in susceptibility to the positive symptoms of FES and to these FES not progressing on to chronic schizophrenia.

Authors


  •   Hui, Li (external author)
  •   Zhang, Xuan (external author)
  •   Huang, Xu-Feng
  •   Han, Mei
  •   Fernandez-Enright, Francesca E.
  •   Yu, Yaqin (external author)
  •   Sun, Shilong (external author)
  •   Li, Wenjun (external author)
  •   Chen, Da Chun (external author)
  •   Xiu, Mei Hong. (external author)
  •   Kosten, Thomas R. (external author)
  •   Zhang, Xiang Yang (external author)

Publication Date


  • 2012

Citation


  • Hui, L., Zhang, X., Huang, X. Feng., Han, M., Fernandez, F., Yu, Y., Sun, S., Li, W., Chen, D. Chun., Xiu, M. Hong., Kosten, T. R. & Zhang, X. Yang. (2012). The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. Journal of Psychiatric Research, 46 (6), 733-737.

Scopus Eid


  • 2-s2.0-84862791804

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3097

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 733

End Page


  • 737

Volume


  • 46

Issue


  • 6

Place Of Publication


  • United Kingdom

Abstract


  • Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative Syndrome Scale (PANSS).

    Results:We showedthat theDBH50-Ins/Del deletion (Del) allelic and genotypic frequencieswere significantly lower in controls than first-episode of schizophrenics (FES) (both p < 0.001), but controlswere not different from chronic schizophrenics. Furthermore, the PANSS positive symptom and total scores were significantly higher in FES with the Del/Del genotype than those with Ins/Del and Ins/Ins genotypes (all p < 0.05). Conclusions: The DBH50-Ins/Del polymorphism may play a role in susceptibility to the positive symptoms of FES and to these FES not progressing on to chronic schizophrenia.

Authors


  •   Hui, Li (external author)
  •   Zhang, Xuan (external author)
  •   Huang, Xu-Feng
  •   Han, Mei
  •   Fernandez-Enright, Francesca E.
  •   Yu, Yaqin (external author)
  •   Sun, Shilong (external author)
  •   Li, Wenjun (external author)
  •   Chen, Da Chun (external author)
  •   Xiu, Mei Hong. (external author)
  •   Kosten, Thomas R. (external author)
  •   Zhang, Xiang Yang (external author)

Publication Date


  • 2012

Citation


  • Hui, L., Zhang, X., Huang, X. Feng., Han, M., Fernandez, F., Yu, Y., Sun, S., Li, W., Chen, D. Chun., Xiu, M. Hong., Kosten, T. R. & Zhang, X. Yang. (2012). The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. Journal of Psychiatric Research, 46 (6), 733-737.

Scopus Eid


  • 2-s2.0-84862791804

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3097

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 733

End Page


  • 737

Volume


  • 46

Issue


  • 6

Place Of Publication


  • United Kingdom