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Quadruplex DNA: a promising drug target for the medicinal inorganic chemist

Journal Article


Abstract


  • Compounds that can bind to and stabilize quadruplex DNA structures in telomeres, or induce formation of such

    structures from ssDNA, represent an attractive general approach to the treatment of cancer. Until recently most effort in

    this area has been directed towards the synthesis of organic compounds for this purpose. More recently there has been

    growing recognition that metal complexes offer a number of potential advantages for the preparation of lead complexes

    that bind with high affinity and selectivity for quadruplex DNA. This review seeks to discuss the work that has been reported

    in this area to date. While most early studies focused on metal complexes of porphyrin ligands, during the past 4

    years there has been a dramatic increase in the number of papers in the literature examining the potential of mononuclear

    complexes of a variety of other ligands, particularly Schiff base ligands and those based on phenanthroline, as quadruplex

    DNA binders and telomerase inhibitors. In addition, there has been growing interest in exploiting supramolecular chemistry

    to prepare novel multinuclear complexes that bind to this new drug target.

Publication Date


  • 2011

Citation


  • Ralph, S. F. (2011). Quadruplex DNA: a promising drug target for the medicinal inorganic chemist. Current Topics in Medicinal Chemistry, 11 (5), 572-590.

Scopus Eid


  • 2-s2.0-79952749516

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 572

End Page


  • 590

Volume


  • 11

Issue


  • 5

Place Of Publication


  • Netherlands

Abstract


  • Compounds that can bind to and stabilize quadruplex DNA structures in telomeres, or induce formation of such

    structures from ssDNA, represent an attractive general approach to the treatment of cancer. Until recently most effort in

    this area has been directed towards the synthesis of organic compounds for this purpose. More recently there has been

    growing recognition that metal complexes offer a number of potential advantages for the preparation of lead complexes

    that bind with high affinity and selectivity for quadruplex DNA. This review seeks to discuss the work that has been reported

    in this area to date. While most early studies focused on metal complexes of porphyrin ligands, during the past 4

    years there has been a dramatic increase in the number of papers in the literature examining the potential of mononuclear

    complexes of a variety of other ligands, particularly Schiff base ligands and those based on phenanthroline, as quadruplex

    DNA binders and telomerase inhibitors. In addition, there has been growing interest in exploiting supramolecular chemistry

    to prepare novel multinuclear complexes that bind to this new drug target.

Publication Date


  • 2011

Citation


  • Ralph, S. F. (2011). Quadruplex DNA: a promising drug target for the medicinal inorganic chemist. Current Topics in Medicinal Chemistry, 11 (5), 572-590.

Scopus Eid


  • 2-s2.0-79952749516

Has Global Citation Frequency


Number Of Pages


  • 18

Start Page


  • 572

End Page


  • 590

Volume


  • 11

Issue


  • 5

Place Of Publication


  • Netherlands