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Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride

Journal Article


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Abstract


  • In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1Hindole

    moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-

    nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally

    characterized. This pyridinium chloride salt crystallized in the monoclinic space group

    P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4)

    Å, β 107.702(7)°, V 1723.2(9) Å3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in

    the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane

    over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°].

UOW Authors


  •   Bremner, John
  •   Samosorn, Siritrin (external author)
  •   Skelton, Brian W. (external author)
  •   White, Allan H. (external author)

Publication Date


  • 2011

Citation


  • Bremner, J. B., Samosorn, S., Skelton, B. W. & White, A. H. (2011). Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride. Molecules, 16 (9), 7627-7633.

Scopus Eid


  • 2-s2.0-80053280302

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6571&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/3229

Number Of Pages


  • 6

Start Page


  • 7627

End Page


  • 7633

Volume


  • 16

Issue


  • 9

Abstract


  • In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1Hindole

    moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-

    nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally

    characterized. This pyridinium chloride salt crystallized in the monoclinic space group

    P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4)

    Å, β 107.702(7)°, V 1723.2(9) Å3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in

    the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane

    over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°].

UOW Authors


  •   Bremner, John
  •   Samosorn, Siritrin (external author)
  •   Skelton, Brian W. (external author)
  •   White, Allan H. (external author)

Publication Date


  • 2011

Citation


  • Bremner, J. B., Samosorn, S., Skelton, B. W. & White, A. H. (2011). Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride. Molecules, 16 (9), 7627-7633.

Scopus Eid


  • 2-s2.0-80053280302

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6571&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/3229

Number Of Pages


  • 6

Start Page


  • 7627

End Page


  • 7633

Volume


  • 16

Issue


  • 9