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Synthesis of novel sugar diamino acids

Conference Paper


Abstract


  • Sugar amino acids (SAAs), which are found in nature as construction elements, are important building blocks for the prepn. of peptide mimetics and oligosaccharides in drug design and development. The synthesis of SAAs is readily accomplished in a few steps and more than 40 SAAs have been synthesized to date. Sugar amino acids with an addnl. amino group, e.g. sugar diamino acid (SDAs), would represent a useful expansion to the library of SAAs available where the carboxylic acid and one of the amino groups would be available for peptide coupling and the addnl. amino group would provide a handle for further derivatisation and/or labeling. However, the synthesis of SDAs is challenging and only three general types have been reported to date (e.g. type 1). Herein, our work towards the synthesis of new SDAs of type 1 and 2 will be presented.

Authors


  •   Thillakan, Mehalai (external author)
  •   Katsifis, Andrew (external author)
  •   Skropeta, Danielle

Publication Date


  • 2010

Citation


  • Thillakan, M., Katsifis, A. & Skropeta, D. (2010). Synthesis of novel sugar diamino acids. Pacifichem 2010, International Chemical Congress of Pacific Basin Societies (pp. 291-291). Washington, DC: American Chemical Society.

Start Page


  • 291

End Page


  • 291

Abstract


  • Sugar amino acids (SAAs), which are found in nature as construction elements, are important building blocks for the prepn. of peptide mimetics and oligosaccharides in drug design and development. The synthesis of SAAs is readily accomplished in a few steps and more than 40 SAAs have been synthesized to date. Sugar amino acids with an addnl. amino group, e.g. sugar diamino acid (SDAs), would represent a useful expansion to the library of SAAs available where the carboxylic acid and one of the amino groups would be available for peptide coupling and the addnl. amino group would provide a handle for further derivatisation and/or labeling. However, the synthesis of SDAs is challenging and only three general types have been reported to date (e.g. type 1). Herein, our work towards the synthesis of new SDAs of type 1 and 2 will be presented.

Authors


  •   Thillakan, Mehalai (external author)
  •   Katsifis, Andrew (external author)
  •   Skropeta, Danielle

Publication Date


  • 2010

Citation


  • Thillakan, M., Katsifis, A. & Skropeta, D. (2010). Synthesis of novel sugar diamino acids. Pacifichem 2010, International Chemical Congress of Pacific Basin Societies (pp. 291-291). Washington, DC: American Chemical Society.

Start Page


  • 291

End Page


  • 291