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Delayed preattentional functioning in early psychosis patients with cannabis use

Journal Article


Abstract


  • Rationale Cannabis use is prevalent among the early psychosis

    (EP) population. The event-related potentials, mismatch

    negativity (MMN) and P3a are reduced in EP.

    Cannabinoids have been shown to modulate N-methyl-Daspartate

    receptors which are involved in MMN generation.

    Objectives This study is the first to investigate the effects of

    cannabis use on MMN/P3a in EP.

    Methods EP was defined as a history of psychosis or psychotic

    symptoms with no progression to date to chronic

    schizophrenia. Twenty-two EP patients with cannabis use

    (EP+CANN), 22 non-cannabis-using EP patients (EPCANN)

    and 21 healthy controls participated in this study.

    MMN/P3a was elicited using a two-tone, auditory paradigm

    with 8% duration deviants.

    Results As expected, EP-CANN showed marked reductions

    in MMN/P3a amplitudes compared to controls. However,

    EP+CANN showed evidence of a different pattern of neurophysiological

    expression of MMN/P3a compared to nonusing

    patients, most notably in terms of delayed frontal

    MMN/P3a latencies.

    Conclusions This study provides further evidence that

    MMN/P3a deficits are present during early psychosis and

    suggests that this biomarker may have utility in differentiating

    substance- from non-substance-related psychoses.

UOW Authors


  •   Pesa, Nicole (external author)
  •   Hermens, Daniel F. (external author)
  •   Battisti, Robert A. (external author)
  •   Kaur, Manreena (external author)
  •   Hickie, Ian B. (external author)
  •   Solowij, Nadia

Publication Date


  • 2012

Citation


  • Pesa, N., Hermens, D. F., Battisti, R. A., Kaur, M., Hickie, I. B. & Solowij, N. (2012). Delayed preattentional functioning in early psychosis patients with cannabis use. Psychopharmacology, 222 (3), 507-518.

Scopus Eid


  • 2-s2.0-84864442091

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3045

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 507

End Page


  • 518

Volume


  • 222

Issue


  • 3

Place Of Publication


  • Germany

Abstract


  • Rationale Cannabis use is prevalent among the early psychosis

    (EP) population. The event-related potentials, mismatch

    negativity (MMN) and P3a are reduced in EP.

    Cannabinoids have been shown to modulate N-methyl-Daspartate

    receptors which are involved in MMN generation.

    Objectives This study is the first to investigate the effects of

    cannabis use on MMN/P3a in EP.

    Methods EP was defined as a history of psychosis or psychotic

    symptoms with no progression to date to chronic

    schizophrenia. Twenty-two EP patients with cannabis use

    (EP+CANN), 22 non-cannabis-using EP patients (EPCANN)

    and 21 healthy controls participated in this study.

    MMN/P3a was elicited using a two-tone, auditory paradigm

    with 8% duration deviants.

    Results As expected, EP-CANN showed marked reductions

    in MMN/P3a amplitudes compared to controls. However,

    EP+CANN showed evidence of a different pattern of neurophysiological

    expression of MMN/P3a compared to nonusing

    patients, most notably in terms of delayed frontal

    MMN/P3a latencies.

    Conclusions This study provides further evidence that

    MMN/P3a deficits are present during early psychosis and

    suggests that this biomarker may have utility in differentiating

    substance- from non-substance-related psychoses.

UOW Authors


  •   Pesa, Nicole (external author)
  •   Hermens, Daniel F. (external author)
  •   Battisti, Robert A. (external author)
  •   Kaur, Manreena (external author)
  •   Hickie, Ian B. (external author)
  •   Solowij, Nadia

Publication Date


  • 2012

Citation


  • Pesa, N., Hermens, D. F., Battisti, R. A., Kaur, M., Hickie, I. B. & Solowij, N. (2012). Delayed preattentional functioning in early psychosis patients with cannabis use. Psychopharmacology, 222 (3), 507-518.

Scopus Eid


  • 2-s2.0-84864442091

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3045

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 507

End Page


  • 518

Volume


  • 222

Issue


  • 3

Place Of Publication


  • Germany