Skip to main content

The acute effects of d-amphetamine and d-methamphetamine on ERP components in humans

Journal Article


Abstract


  • While a number of behavioural studies have been conducted to investigate the acute effects of amphetamines

    on tasks of attention and information processing, there is currently a scarcity of research

    concerning their electrophysiological effects in healthy adults. It is also unclear as to

    whether amphetamines exert effects on stimulus evaluation or response selection. In two studies,

    independent groups of twenty healthy illicit stimulant users aged between 21 and 32 years were administered

    0.42 mg/kg d-amphetamine versus placebo, and 0.42 mg/kg d-methamphetamine versus

    placebo respectively, and completed an auditory oddball task on two separate testing days. A

    62-channel EEG was recorded during the completion of the task, and the effects of amphetamines

    on N200 and P300 ERP components were analysed. d-amphetamine significantly decreased reaction

    time, improved accuracy, and reduced the latency of the P300 component relative to placebo,

    while having no effect on the N200 component. d-methamphetamine had no effect on reaction

    time, accuracy or the P300 component, but reduced the amplitude of the N200 component, relative

    to placebo. It was concluded that there is tentative support to suggest that d-amphetamine at a

    dose of 0.42 mg/kg may enhance speed of information processing while d-methamphetamine at a

    dose of 0.42 mg/kg may reflect changes to stimulus evaluation.

Authors


  •   Silber, Beata (external author)
  •   Croft, Rodney J.
  •   Camfield, David A. (external author)
  •   Downey, Luke (external author)
  •   Papafotiou, Katherine (external author)
  •   Stough, Con K. (external author)

Publication Date


  • 2012

Citation


  • Silber, B., Croft, R., Camfield, D. A., Downey, L. A., Papafotiou, K. & Stough, C. (2012). The acute effects of d-amphetamine and d-methamphetamine on ERP components in humans. European Neuropsychopharmacology, 22 (7), 492-500.

Scopus Eid


  • 2-s2.0-84861483936

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2796

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 492

End Page


  • 500

Volume


  • 22

Issue


  • 7

Place Of Publication


  • Netherlands

Abstract


  • While a number of behavioural studies have been conducted to investigate the acute effects of amphetamines

    on tasks of attention and information processing, there is currently a scarcity of research

    concerning their electrophysiological effects in healthy adults. It is also unclear as to

    whether amphetamines exert effects on stimulus evaluation or response selection. In two studies,

    independent groups of twenty healthy illicit stimulant users aged between 21 and 32 years were administered

    0.42 mg/kg d-amphetamine versus placebo, and 0.42 mg/kg d-methamphetamine versus

    placebo respectively, and completed an auditory oddball task on two separate testing days. A

    62-channel EEG was recorded during the completion of the task, and the effects of amphetamines

    on N200 and P300 ERP components were analysed. d-amphetamine significantly decreased reaction

    time, improved accuracy, and reduced the latency of the P300 component relative to placebo,

    while having no effect on the N200 component. d-methamphetamine had no effect on reaction

    time, accuracy or the P300 component, but reduced the amplitude of the N200 component, relative

    to placebo. It was concluded that there is tentative support to suggest that d-amphetamine at a

    dose of 0.42 mg/kg may enhance speed of information processing while d-methamphetamine at a

    dose of 0.42 mg/kg may reflect changes to stimulus evaluation.

Authors


  •   Silber, Beata (external author)
  •   Croft, Rodney J.
  •   Camfield, David A. (external author)
  •   Downey, Luke (external author)
  •   Papafotiou, Katherine (external author)
  •   Stough, Con K. (external author)

Publication Date


  • 2012

Citation


  • Silber, B., Croft, R., Camfield, D. A., Downey, L. A., Papafotiou, K. & Stough, C. (2012). The acute effects of d-amphetamine and d-methamphetamine on ERP components in humans. European Neuropsychopharmacology, 22 (7), 492-500.

Scopus Eid


  • 2-s2.0-84861483936

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2796

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 492

End Page


  • 500

Volume


  • 22

Issue


  • 7

Place Of Publication


  • Netherlands