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The effect of d,l-methamphetamine on simulated driving performance

Journal Article


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Abstract


  • Rationale Illicit drugs such as methamphetamine are commonly

    abused drugs that have also been observed to be

    prevalent in drivers injured in road accidents. The exact effect

    of methamphetamine or its specific isomers on driving and

    driving behaviour have yet to be thoroughly investigated.

    Methods Twenty healthy recreational illicit stimulant users

    (ten males, ten females), aged between 21 and 34 years

    (mean=24.3 years, SD=3.4 years), attended two testing

    sessions involving oral consumption of 0.42 mg/kg d,lmethamphetamine

    or a matching placebo. The drug

    administration was counterbalanced, double-blind, and

    medically supervised. At each session, driving performance

    was assessed 2.5 h post-drug administration.

    Results Mean blood and saliva d,l-methamphetamine concentrations

    of approximately 90 and 400 ng/ml, respectively,

    at 2 h and 95 and 475 ng/ml at 3 h were observed. These

    levels of d,l-methamphetamine were found not to significantly

    impair, or improve, driving performance at the 2.5-

    h post-drug administration time point.

    Conclusions The findings of this study illustrate that d,lmethamphetamine

    has no significant effect on simulated

    driving performance.

Authors


  •   Silber, Beata (external author)
  •   Croft, Rodney J.
  •   Downey, Luke (external author)
  •   Camfield, David A. (external author)
  •   Papafotiou, Katherine (external author)
  •   Swann, Phillip (external author)
  •   Stough, Con K. (external author)

Publication Date


  • 2012

Citation


  • Silber, B. Y., Croft, R. J., Downey, L. A., Camfield, D. A., Papafotiou, K., Swann, P. & Stough, C. (2012). The effect of d,l-methamphetamine on simulated driving performance. Psychopharmacology, 219 (4), 1081-1087.

Scopus Eid


  • 2-s2.0-84856639461

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2166&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1117

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 1081

End Page


  • 1087

Volume


  • 219

Issue


  • 4

Place Of Publication


  • Germany

Abstract


  • Rationale Illicit drugs such as methamphetamine are commonly

    abused drugs that have also been observed to be

    prevalent in drivers injured in road accidents. The exact effect

    of methamphetamine or its specific isomers on driving and

    driving behaviour have yet to be thoroughly investigated.

    Methods Twenty healthy recreational illicit stimulant users

    (ten males, ten females), aged between 21 and 34 years

    (mean=24.3 years, SD=3.4 years), attended two testing

    sessions involving oral consumption of 0.42 mg/kg d,lmethamphetamine

    or a matching placebo. The drug

    administration was counterbalanced, double-blind, and

    medically supervised. At each session, driving performance

    was assessed 2.5 h post-drug administration.

    Results Mean blood and saliva d,l-methamphetamine concentrations

    of approximately 90 and 400 ng/ml, respectively,

    at 2 h and 95 and 475 ng/ml at 3 h were observed. These

    levels of d,l-methamphetamine were found not to significantly

    impair, or improve, driving performance at the 2.5-

    h post-drug administration time point.

    Conclusions The findings of this study illustrate that d,lmethamphetamine

    has no significant effect on simulated

    driving performance.

Authors


  •   Silber, Beata (external author)
  •   Croft, Rodney J.
  •   Downey, Luke (external author)
  •   Camfield, David A. (external author)
  •   Papafotiou, Katherine (external author)
  •   Swann, Phillip (external author)
  •   Stough, Con K. (external author)

Publication Date


  • 2012

Citation


  • Silber, B. Y., Croft, R. J., Downey, L. A., Camfield, D. A., Papafotiou, K., Swann, P. & Stough, C. (2012). The effect of d,l-methamphetamine on simulated driving performance. Psychopharmacology, 219 (4), 1081-1087.

Scopus Eid


  • 2-s2.0-84856639461

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2166&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1117

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 1081

End Page


  • 1087

Volume


  • 219

Issue


  • 4

Place Of Publication


  • Germany