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Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide

Journal Article


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Abstract


  • As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction.

UOW Authors


Publication Date


  • 2012

Citation


  • Swamy, N. Kumara. & Pyne, S. G. (2012). Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide. Heterocycles, 84 (1), 473-492.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1175&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/176

Number Of Pages


  • 19

Start Page


  • 473

End Page


  • 492

Volume


  • 84

Issue


  • 1

Abstract


  • As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction.

UOW Authors


Publication Date


  • 2012

Citation


  • Swamy, N. Kumara. & Pyne, S. G. (2012). Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide. Heterocycles, 84 (1), 473-492.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1175&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/176

Number Of Pages


  • 19

Start Page


  • 473

End Page


  • 492

Volume


  • 84

Issue


  • 1