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Effect of a static magnetic field on nanodosimetric quantities in a DNA volume

Journal Article


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Abstract


  • Abstract

    Purpose: With the advent of magnetic resonance imaging (MRI)-guided radiation therapy it is becoming increasingly important to consider the potential influence of a magnetic field on ionising radiation. This paper aims to study the effect of a magnetic field on the track structure of radiation to determine if the biological effectiveness may be altered.

    Methods: Using the Geant4-DNA (GEometry ANd Tracking 4) Monte Carlo simulation toolkit, nanodosimetric track structure parameters were calculated for electrons, protons and alpha particles moving in transverse magnetic fields up to 10 Tesla. Applying the model proposed by Garty et al., the track structure parameters were used to derive the probability of producing a double-strand break (DSB).

    Results: For simulated primary particles of electrons (200 eV–10 keV), protons (300 keV–30 MeV) and alpha particles (1–9 MeV) the application of a magnetic field was shown to have no significant effect (within statistical uncertainty limits) on the parameters characterizing radiation track structure or the probability of producing a DSB.

    Conclusions: The null result found here implies that if the presence of a magnetic field were to induce a change in the biological effectiveness of radiation, the effect would likely not be due to a change in the track structure of the radiation.

Authors


  •   Lazarakis, Peter (external author)
  •   Bug, Marion (external author)
  •   Gargioni, E (external author)
  •   Guatelli, Susanna
  •   Incerti, Sebastian (external author)
  •   Rabus, Hans (external author)
  •   Rosenfeld, Anatoly B.

Publication Date


  • 2012

Citation


  • Lazarakis, P., Bug, M. U., Gargioni, E., Guatelli, S., Incerti, S., Rabus, H. & Rozenfeld, A. (2012). Effect of a static magnetic field on nanodosimetric quantities in a DNA volume. International Journal of Radiation Biology, 88 (1-2), 183-188.

Scopus Eid


  • 2-s2.0-84855411587

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5513&context=engpapers&unstamped=1

Ro Metadata Url


  • http://ro.uow.edu.au/engpapers/2582

Number Of Pages


  • 5

Start Page


  • 183

End Page


  • 188

Volume


  • 88

Issue


  • 1-2

Abstract


  • Abstract

    Purpose: With the advent of magnetic resonance imaging (MRI)-guided radiation therapy it is becoming increasingly important to consider the potential influence of a magnetic field on ionising radiation. This paper aims to study the effect of a magnetic field on the track structure of radiation to determine if the biological effectiveness may be altered.

    Methods: Using the Geant4-DNA (GEometry ANd Tracking 4) Monte Carlo simulation toolkit, nanodosimetric track structure parameters were calculated for electrons, protons and alpha particles moving in transverse magnetic fields up to 10 Tesla. Applying the model proposed by Garty et al., the track structure parameters were used to derive the probability of producing a double-strand break (DSB).

    Results: For simulated primary particles of electrons (200 eV–10 keV), protons (300 keV–30 MeV) and alpha particles (1–9 MeV) the application of a magnetic field was shown to have no significant effect (within statistical uncertainty limits) on the parameters characterizing radiation track structure or the probability of producing a DSB.

    Conclusions: The null result found here implies that if the presence of a magnetic field were to induce a change in the biological effectiveness of radiation, the effect would likely not be due to a change in the track structure of the radiation.

Authors


  •   Lazarakis, Peter (external author)
  •   Bug, Marion (external author)
  •   Gargioni, E (external author)
  •   Guatelli, Susanna
  •   Incerti, Sebastian (external author)
  •   Rabus, Hans (external author)
  •   Rosenfeld, Anatoly B.

Publication Date


  • 2012

Citation


  • Lazarakis, P., Bug, M. U., Gargioni, E., Guatelli, S., Incerti, S., Rabus, H. & Rozenfeld, A. (2012). Effect of a static magnetic field on nanodosimetric quantities in a DNA volume. International Journal of Radiation Biology, 88 (1-2), 183-188.

Scopus Eid


  • 2-s2.0-84855411587

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5513&context=engpapers&unstamped=1

Ro Metadata Url


  • http://ro.uow.edu.au/engpapers/2582

Number Of Pages


  • 5

Start Page


  • 183

End Page


  • 188

Volume


  • 88

Issue


  • 1-2