Skip to main content
placeholder image

Diagnostic and treatment challenges of negative symptoms in schizophrenia

Journal Article


Abstract


  • Background: Negative symptoms (NSs) are a major contributor to the

    poor quality of life people with schizophrenia and are the most important

    cause of long- term disability. Recent evidence has shown that

    15-25% of people with schizophrenia experience NSs which warrant

    treatment. The purpose of this paper is to address issues of diagnostic

    and treatment challenges of NSs.

    Method: NSs are multifactorial in origin and it is diffi cult to differentiate

    between primary and secondary NSs. The primary NSs or ‘ defi cit

    symptoms ’ are due to underlying disorder whereas secondary NSs are

    secondary to positive psychotic symptoms, extra-pyramidal side effects

    of anti psychotic medication, depression and catatonia. Andreasen

    includes NSs of affective fl attening, alogia, avolition, anhedonia, and

    attention, which in turn are defi ned by a number of symptoms as

    refl ected by the Scale for the Assessment of Negative Symptoms

    (SANS). It is diffi cult to differentiate between NSs and that of depression.

    Amongst all atypical antipsychotics clozapine has a good effect

    on the secondary NSs but not on primary. Other specifi c psychosocial

    interventions have some benefi cial effects on NSs include cognitive

    remediation, CBT, social skills training and group therapies involving

    multiple families.

    Conclusion: NSs are hard to defi ne as they are more subjective than the

    presence of positive symptoms. They are nonspecifi c and may mimic

    depression. Accurate assessment of NSs requires robust standard rating

    scales. More research is required to understand the psychopathology of

    NSs and to fi nd out more effi cacious interventions of their management.

Publication Date


  • 2010

Citation


  • Panesar, N., Garg, V. & Pai, N. Brahmavar. (2010). Diagnostic and treatment challenges of negative symptoms in schizophrenia. In 11th Australasian Schizophrenia Conference, 22-24 September, Sydney. Australian and New Zealand Journal of Psychiatry, 44 (S1), A46-A47.

Ro Metadata Url


  • http://ro.uow.edu.au/medpapers/276

Start Page


  • A46

End Page


  • A47

Volume


  • 44

Issue


  • S1

Place Of Publication


  • Australia

Abstract


  • Background: Negative symptoms (NSs) are a major contributor to the

    poor quality of life people with schizophrenia and are the most important

    cause of long- term disability. Recent evidence has shown that

    15-25% of people with schizophrenia experience NSs which warrant

    treatment. The purpose of this paper is to address issues of diagnostic

    and treatment challenges of NSs.

    Method: NSs are multifactorial in origin and it is diffi cult to differentiate

    between primary and secondary NSs. The primary NSs or ‘ defi cit

    symptoms ’ are due to underlying disorder whereas secondary NSs are

    secondary to positive psychotic symptoms, extra-pyramidal side effects

    of anti psychotic medication, depression and catatonia. Andreasen

    includes NSs of affective fl attening, alogia, avolition, anhedonia, and

    attention, which in turn are defi ned by a number of symptoms as

    refl ected by the Scale for the Assessment of Negative Symptoms

    (SANS). It is diffi cult to differentiate between NSs and that of depression.

    Amongst all atypical antipsychotics clozapine has a good effect

    on the secondary NSs but not on primary. Other specifi c psychosocial

    interventions have some benefi cial effects on NSs include cognitive

    remediation, CBT, social skills training and group therapies involving

    multiple families.

    Conclusion: NSs are hard to defi ne as they are more subjective than the

    presence of positive symptoms. They are nonspecifi c and may mimic

    depression. Accurate assessment of NSs requires robust standard rating

    scales. More research is required to understand the psychopathology of

    NSs and to fi nd out more effi cacious interventions of their management.

Publication Date


  • 2010

Citation


  • Panesar, N., Garg, V. & Pai, N. Brahmavar. (2010). Diagnostic and treatment challenges of negative symptoms in schizophrenia. In 11th Australasian Schizophrenia Conference, 22-24 September, Sydney. Australian and New Zealand Journal of Psychiatry, 44 (S1), A46-A47.

Ro Metadata Url


  • http://ro.uow.edu.au/medpapers/276

Start Page


  • A46

End Page


  • A47

Volume


  • 44

Issue


  • S1

Place Of Publication


  • Australia