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An improved synthesis of 2-(1,2,4-thiadiazol-5-yl)pyridine by interception of an intermediate involved in a competing cyclisation reaction.

Journal Article


Abstract


  • Reaction of thiopicolinamide with N,N′-dimethylformamide dimethyl acetal leads to the formation of 3-(dimethylamino)-1-methylthioimidazo[1,5-a]pyridine (3). However, the course of the reaction can be diverted to produce the title compound (1) in good yield by timely interception of the intermediate thioacylamidine (2). © 2007 Elsevier Ltd. All rights reserved.

Publication Date


  • 2007

Citation


  • Richardson, C. & Steel, P. J. (2007). An improved synthesis of 2-(1,2,4-thiadiazol-5-yl)pyridine by interception of an intermediate involved in a competing cyclisation reaction.. Tetrahedron Letters, 48 (26), 4553-4555.

Scopus Eid


  • 2-s2.0-34249296641

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4899

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 4553

End Page


  • 4555

Volume


  • 48

Issue


  • 26

Abstract


  • Reaction of thiopicolinamide with N,N′-dimethylformamide dimethyl acetal leads to the formation of 3-(dimethylamino)-1-methylthioimidazo[1,5-a]pyridine (3). However, the course of the reaction can be diverted to produce the title compound (1) in good yield by timely interception of the intermediate thioacylamidine (2). © 2007 Elsevier Ltd. All rights reserved.

Publication Date


  • 2007

Citation


  • Richardson, C. & Steel, P. J. (2007). An improved synthesis of 2-(1,2,4-thiadiazol-5-yl)pyridine by interception of an intermediate involved in a competing cyclisation reaction.. Tetrahedron Letters, 48 (26), 4553-4555.

Scopus Eid


  • 2-s2.0-34249296641

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4899

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 4553

End Page


  • 4555

Volume


  • 48

Issue


  • 26