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Kinase inhibitors from marine sponges

Journal Article


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Abstract


  • Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.

Authors


  •   Skropeta, Danielle
  •   Pastro, Natalie J. (external author)
  •   Zivanovic, Ana (external author)

Publication Date


  • 2011

Citation


  • Skropeta, D., Pastro, N. & Zivanovic, A. (2011). Kinase inhibitors from marine sponges. Marine Drugs, 9 (10), 2131-2154.

Scopus Eid


  • 2-s2.0-80054882118

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8612&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5269

Number Of Pages


  • 23

Start Page


  • 2131

End Page


  • 2154

Volume


  • 9

Issue


  • 10

Place Of Publication


  • http://www.mdpi.com//1660-3397/9/10/2131/

Abstract


  • Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.

Authors


  •   Skropeta, Danielle
  •   Pastro, Natalie J. (external author)
  •   Zivanovic, Ana (external author)

Publication Date


  • 2011

Citation


  • Skropeta, D., Pastro, N. & Zivanovic, A. (2011). Kinase inhibitors from marine sponges. Marine Drugs, 9 (10), 2131-2154.

Scopus Eid


  • 2-s2.0-80054882118

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8612&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5269

Number Of Pages


  • 23

Start Page


  • 2131

End Page


  • 2154

Volume


  • 9

Issue


  • 10

Place Of Publication


  • http://www.mdpi.com//1660-3397/9/10/2131/