Skip to main content

Dietary fish oil preserves cardiac function in the hypertrophied rat heart

Journal Article


Download full-text (Open Access)

Abstract


  • Regular fish or fish oil intake is associated with a low incidence of heart failure clinically, and fish oil-induced reduction in cardiac remodelling seen in hypertrophy models may contribute. We investigated whether improved cardiac energy efficiency in non-hypertrophied hearts translates into attenuation of cardiac dysfunction in hypertrophied hearts. Male Wistar rats (n 33) at 8 weeks of age were sham- operated or subjected to abdominal aortic stenosis to produce pressure-overload cardiac hypertrophy. Starting 3 weeks post-operatively to follow initiation of hypertrophy, rats were fed a diet containing 10% olive oil (control) or 5% fish oil (ROPUFA┬« 30 (17% EPA, 10% DHA)) + 5% olive oil (FO diet). At 15 weeks post-operatively, ventricular haemodynamics and oxygen consumption were evaluated in the blood-perfused, isolated working heart. Resting and maximally stimulated cardiac output and external work were >60% depressed in hypertrophied control hearts but this was prevented by FO feeding, without attenuating hypertrophy. Cardiac energy efficiency was lower in hypertrophy, but greater in FO hearts for any given cardiac mass. Coronary blood flow, restricted in hypertrophied control hearts, increased with increasing work in hypertrophied FO hearts, revealing a significant coronary vasodilator reserve. Pronounced cardiac dysfunction in hypertrophied hearts across low and high workloads, indicative of heart failure, was attenuated by FO feeding in association with membrane incorporation of n-3 PUFA, principally DHA. Dietary fish oil may offer a new approach to balancing the high oxygen demand and haemodynamic requirements of the failing hypertrophied heart independently of attenuating hypertrophy.

Authors


  •   McLennan, Peter L.
  •   Abeywardena, MY (external author)
  •   Dallimore, Julie A. (external author)
  •   Raederstorff, Daniel (external author)

Publication Date


  • 2011

Citation


  • McLennan, P. L., Abeywardena, M. Y., Dallimore, J. A. & Raederstorff, D. (2012). Dietary fish oil preserves cardiac function in the hypertrophied rat heart. The British Journal of Nutrition: an international journal of nutritional science, 108 (4), 645-654.

Scopus Eid


  • 2-s2.0-84865238259

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1438&context=medpapers

Ro Metadata Url


  • http://ro.uow.edu.au/medpapers/434

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 645

End Page


  • 654

Volume


  • 108

Issue


  • 4

Place Of Publication


  • United Kingdom

Abstract


  • Regular fish or fish oil intake is associated with a low incidence of heart failure clinically, and fish oil-induced reduction in cardiac remodelling seen in hypertrophy models may contribute. We investigated whether improved cardiac energy efficiency in non-hypertrophied hearts translates into attenuation of cardiac dysfunction in hypertrophied hearts. Male Wistar rats (n 33) at 8 weeks of age were sham- operated or subjected to abdominal aortic stenosis to produce pressure-overload cardiac hypertrophy. Starting 3 weeks post-operatively to follow initiation of hypertrophy, rats were fed a diet containing 10% olive oil (control) or 5% fish oil (ROPUFA┬« 30 (17% EPA, 10% DHA)) + 5% olive oil (FO diet). At 15 weeks post-operatively, ventricular haemodynamics and oxygen consumption were evaluated in the blood-perfused, isolated working heart. Resting and maximally stimulated cardiac output and external work were >60% depressed in hypertrophied control hearts but this was prevented by FO feeding, without attenuating hypertrophy. Cardiac energy efficiency was lower in hypertrophy, but greater in FO hearts for any given cardiac mass. Coronary blood flow, restricted in hypertrophied control hearts, increased with increasing work in hypertrophied FO hearts, revealing a significant coronary vasodilator reserve. Pronounced cardiac dysfunction in hypertrophied hearts across low and high workloads, indicative of heart failure, was attenuated by FO feeding in association with membrane incorporation of n-3 PUFA, principally DHA. Dietary fish oil may offer a new approach to balancing the high oxygen demand and haemodynamic requirements of the failing hypertrophied heart independently of attenuating hypertrophy.

Authors


  •   McLennan, Peter L.
  •   Abeywardena, MY (external author)
  •   Dallimore, Julie A. (external author)
  •   Raederstorff, Daniel (external author)

Publication Date


  • 2011

Citation


  • McLennan, P. L., Abeywardena, M. Y., Dallimore, J. A. & Raederstorff, D. (2012). Dietary fish oil preserves cardiac function in the hypertrophied rat heart. The British Journal of Nutrition: an international journal of nutritional science, 108 (4), 645-654.

Scopus Eid


  • 2-s2.0-84865238259

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1438&context=medpapers

Ro Metadata Url


  • http://ro.uow.edu.au/medpapers/434

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 645

End Page


  • 654

Volume


  • 108

Issue


  • 4

Place Of Publication


  • United Kingdom