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Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma

Journal Article


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Abstract


  • Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances that prevent PAI-2 upregulation are associated with chronic pathology. Altogether this strongly suggests that PAI-2 is one of the many proteins that maintain homeostasis during damage or stress. However, several functions ranging from a classical serpin to various intracellular roles have been ascribed to PAI-2 and, because none of these have been definitively proven in vivo, to this day its precise role or roles remains an enigma. This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2.

Authors


  •   Lee, Jodi (external author)
  •   Cochran, Blake (external author)
  •   Lobov, Sergei A. (external author)
  •   Ranson, Marie

Publication Date


  • 2011

Citation


  • Lee, J. A., Cochran, B. J., Lobov, S. A. & Ranson, M. (2011). Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma. Seminars in Thrombosis and Hemostasis, 37 (4), 395-407.

Scopus Eid


  • 2-s2.0-79961036605

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1127&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/112

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 395

End Page


  • 407

Volume


  • 37

Issue


  • 4

Abstract


  • Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances that prevent PAI-2 upregulation are associated with chronic pathology. Altogether this strongly suggests that PAI-2 is one of the many proteins that maintain homeostasis during damage or stress. However, several functions ranging from a classical serpin to various intracellular roles have been ascribed to PAI-2 and, because none of these have been definitively proven in vivo, to this day its precise role or roles remains an enigma. This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2.

Authors


  •   Lee, Jodi (external author)
  •   Cochran, Blake (external author)
  •   Lobov, Sergei A. (external author)
  •   Ranson, Marie

Publication Date


  • 2011

Citation


  • Lee, J. A., Cochran, B. J., Lobov, S. A. & Ranson, M. (2011). Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma. Seminars in Thrombosis and Hemostasis, 37 (4), 395-407.

Scopus Eid


  • 2-s2.0-79961036605

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1127&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/112

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 395

End Page


  • 407

Volume


  • 37

Issue


  • 4