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Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring

Journal Article


Abstract


  • Rationale Developmental vitamin D (DVD) deficiency is a

    candidate risk factor for developing schizophrenia in

    humans. In rodents DVD deficiency induces subtle changes

    in the way the brain develops. This early developmental

    insult leads to select behavioural changes in the adult, such

    as an enhanced response to amphetamine-induced locomotion

    in female DVD-deficient rats but not in male DVDdeficient

    rats and an enhanced locomotor response to the Nmethyl-

    D-aspartate (NMDA) receptor antagonist, MK-801,

    in male DVD-deficient rats. However, the response to MK-

    801-induced locomotion in female DVD-deficient rats is

    unknown. Therefore, the aim of the current study was to

    further examine this behavioural finding in male and

    female rats and assess NMDA receptor density.

    Methods DVD-deficient Sprague Dawley rats were

    assessed for locomotion, ataxia, acoustic startle response

    (ASR) and prepulse inhibition (PPI) of the ASR to multiple

    doses of MK-801. The NMDA receptor density in relevant

    brain regions was assessed in a drug-naive cohort.

    Results DVD deficiency increased locomotion in response

    to MK-801 in both sexes. DVD-deficient rats also showed

    an enhanced ASR compared with control rats, but PPI was

    normal. Moreover, DVD deficiency decreased NMDA

    receptor density in the caudate putamen of both sexes.

    Conclusions These results suggest that a transient prenatal

    vitamin D deficiency has a long-lasting effect on NMDAmediated

    signalling in the rodent brain and may be a

    plausible candidate risk factor for schizophrenia and other

    neuropsychiatric disorders.

Authors


  •   Kesby, J (external author)
  •   O'Loan, Jonathan C. (external author)
  •   Alexander, Suzanne (external author)
  •   Deng, Chao
  •   Huang, Xu-Feng
  •   McGrath, John (external author)
  •   Dr Darryl Eyles, Darryl W. (external author)
  •   Burne, Thomas H. J. (external author)

Publication Date


  • 2012

Citation


  • Kesby, J. P., O'Loan, J. C., Alexander, S., Deng, C., Huang, X., McGrath, J. J., Eyles, D. W. & Burne, T. H. J. (2012). Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring. Psychopharmacology, 220 (3), 455-463.

Scopus Eid


  • 2-s2.0-84858414897

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3041

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 455

End Page


  • 463

Volume


  • 220

Issue


  • 3

Place Of Publication


  • Germany

Abstract


  • Rationale Developmental vitamin D (DVD) deficiency is a

    candidate risk factor for developing schizophrenia in

    humans. In rodents DVD deficiency induces subtle changes

    in the way the brain develops. This early developmental

    insult leads to select behavioural changes in the adult, such

    as an enhanced response to amphetamine-induced locomotion

    in female DVD-deficient rats but not in male DVDdeficient

    rats and an enhanced locomotor response to the Nmethyl-

    D-aspartate (NMDA) receptor antagonist, MK-801,

    in male DVD-deficient rats. However, the response to MK-

    801-induced locomotion in female DVD-deficient rats is

    unknown. Therefore, the aim of the current study was to

    further examine this behavioural finding in male and

    female rats and assess NMDA receptor density.

    Methods DVD-deficient Sprague Dawley rats were

    assessed for locomotion, ataxia, acoustic startle response

    (ASR) and prepulse inhibition (PPI) of the ASR to multiple

    doses of MK-801. The NMDA receptor density in relevant

    brain regions was assessed in a drug-naive cohort.

    Results DVD deficiency increased locomotion in response

    to MK-801 in both sexes. DVD-deficient rats also showed

    an enhanced ASR compared with control rats, but PPI was

    normal. Moreover, DVD deficiency decreased NMDA

    receptor density in the caudate putamen of both sexes.

    Conclusions These results suggest that a transient prenatal

    vitamin D deficiency has a long-lasting effect on NMDAmediated

    signalling in the rodent brain and may be a

    plausible candidate risk factor for schizophrenia and other

    neuropsychiatric disorders.

Authors


  •   Kesby, J (external author)
  •   O'Loan, Jonathan C. (external author)
  •   Alexander, Suzanne (external author)
  •   Deng, Chao
  •   Huang, Xu-Feng
  •   McGrath, John (external author)
  •   Dr Darryl Eyles, Darryl W. (external author)
  •   Burne, Thomas H. J. (external author)

Publication Date


  • 2012

Citation


  • Kesby, J. P., O'Loan, J. C., Alexander, S., Deng, C., Huang, X., McGrath, J. J., Eyles, D. W. & Burne, T. H. J. (2012). Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring. Psychopharmacology, 220 (3), 455-463.

Scopus Eid


  • 2-s2.0-84858414897

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3041

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 455

End Page


  • 463

Volume


  • 220

Issue


  • 3

Place Of Publication


  • Germany