Skip to main content

Glutathione transferases: a structural perspective

Journal Article


Download full-text (Open Access)

Abstract


  • The glutathione transferases (GSTs) are one of the most important families of detoxifying enzymes in nature. The classic activity of the GSTs is conjugation of compounds with electrophilic centers to the tripeptide glutathione (GSH), but many other activities are now associated with GSTs, including steroid and leukotriene biosynthesis, peroxide degradation, double-bond cis-trans isomerization, dehydroascorbate reduction, Michael addition, and noncatalytic “ligandin” activity (ligand binding and transport). Since the first GST structure was determined in 1991, there has been an explosion in structural data across GSTs of all three families: the cytosolic GSTs, the mitochondrial GSTs, and the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG family). In this review, the major insights into GST structure and function will be discussed.

Publication Date


  • 2011

Citation


  • Oakley, A. J. (2011). Glutathione transferases: a structural perspective. Drug Metabolism Reviews, 43 (2), 138-151.

Scopus Eid


  • 2-s2.0-79954572279

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8609&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5266

Number Of Pages


  • 13

Start Page


  • 138

End Page


  • 151

Volume


  • 43

Issue


  • 2

Abstract


  • The glutathione transferases (GSTs) are one of the most important families of detoxifying enzymes in nature. The classic activity of the GSTs is conjugation of compounds with electrophilic centers to the tripeptide glutathione (GSH), but many other activities are now associated with GSTs, including steroid and leukotriene biosynthesis, peroxide degradation, double-bond cis-trans isomerization, dehydroascorbate reduction, Michael addition, and noncatalytic “ligandin” activity (ligand binding and transport). Since the first GST structure was determined in 1991, there has been an explosion in structural data across GSTs of all three families: the cytosolic GSTs, the mitochondrial GSTs, and the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG family). In this review, the major insights into GST structure and function will be discussed.

Publication Date


  • 2011

Citation


  • Oakley, A. J. (2011). Glutathione transferases: a structural perspective. Drug Metabolism Reviews, 43 (2), 138-151.

Scopus Eid


  • 2-s2.0-79954572279

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=8609&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5266

Number Of Pages


  • 13

Start Page


  • 138

End Page


  • 151

Volume


  • 43

Issue


  • 2