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Peroxisome proliferator-activated receptor alpha target genes

Journal Article


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Abstract


  • The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation

    of a variety of processes, ranging from inflammation and immunity to nutrientmetabolism and energy homeostasis. PPARα serves

    as amolecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is

    activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression

    of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target

    genes. Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed

    analysis of the different known or putative PPARα target genes. The emphasis is on gene regulation by PPARα in liver although

    many of the results likely apply to other organs and tissues as well.

UOW Authors


  •   Rakhshandehroo, Maryam (external author)
  •   Suesse, Bianca
  •   Muller, Michael (external author)
  •   Kersten, Sander (external author)

Publication Date


  • 2010

Citation


  • Rakhshandehroo, M., Knock, B., Muller, M. & Kersten, S. (2010). Peroxisome proliferator-activated receptor alpha target genes. PPAR Research, 2010 (Article ID 612089), 1-20.

Scopus Eid


  • 2-s2.0-78349283454

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1026&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/12

Has Global Citation Frequency


Number Of Pages


  • 19

Start Page


  • 1

End Page


  • 20

Volume


  • 2010

Issue


  • Article ID 612089

Abstract


  • The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation

    of a variety of processes, ranging from inflammation and immunity to nutrientmetabolism and energy homeostasis. PPARα serves

    as amolecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is

    activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression

    of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target

    genes. Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed

    analysis of the different known or putative PPARα target genes. The emphasis is on gene regulation by PPARα in liver although

    many of the results likely apply to other organs and tissues as well.

UOW Authors


  •   Rakhshandehroo, Maryam (external author)
  •   Suesse, Bianca
  •   Muller, Michael (external author)
  •   Kersten, Sander (external author)

Publication Date


  • 2010

Citation


  • Rakhshandehroo, M., Knock, B., Muller, M. & Kersten, S. (2010). Peroxisome proliferator-activated receptor alpha target genes. PPAR Research, 2010 (Article ID 612089), 1-20.

Scopus Eid


  • 2-s2.0-78349283454

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1026&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/12

Has Global Citation Frequency


Number Of Pages


  • 19

Start Page


  • 1

End Page


  • 20

Volume


  • 2010

Issue


  • Article ID 612089