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Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice

Journal Article


Abstract

  • This study tested the effects of (1-3),(1-4) b-D-glucan from oats, on activation of the guthypothalamic

    (PYY3–36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of b-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, po0.05) and body weight gain was lower with increasing b-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest b-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.

    Keywords:

    b-Glucan / Energy intake / Neuropeptide Y / Obesity / Satiety

Publication Date

  • 2011

Citation

  • Huang, X., Yu, Y., Beck, E., South, T., Li, Y., Batterham, M., Tapsell, L. C. & Chen, J. (2011). Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice. Molecular Nutrition and Food Research, 55 (7), 1118-1121.

Scopus Eid

  • 2-s2.0-79959919777

Ro Metadata Url

  • http://ro.uow.edu.au/smhpapers/1

Has Global Citation Frequency

Number Of Pages

  • 3

Start Page

  • 1118

End Page

  • 1121

Volume

  • 55

Issue

  • 7

Place Of Publication

  • Germany

Abstract

  • This study tested the effects of (1-3),(1-4) b-D-glucan from oats, on activation of the guthypothalamic

    (PYY3–36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of b-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, po0.05) and body weight gain was lower with increasing b-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest b-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.

    Keywords:

    b-Glucan / Energy intake / Neuropeptide Y / Obesity / Satiety

Publication Date

  • 2011

Citation

  • Huang, X., Yu, Y., Beck, E., South, T., Li, Y., Batterham, M., Tapsell, L. C. & Chen, J. (2011). Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice. Molecular Nutrition and Food Research, 55 (7), 1118-1121.

Scopus Eid

  • 2-s2.0-79959919777

Ro Metadata Url

  • http://ro.uow.edu.au/smhpapers/1

Has Global Citation Frequency

Number Of Pages

  • 3

Start Page

  • 1118

End Page

  • 1121

Volume

  • 55

Issue

  • 7

Place Of Publication

  • Germany