Skip to main content

Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia

Journal Article


Download full-text (Open Access)

Abstract


  • Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate

    receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that

    have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and

    functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and

    protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the functioning of the other. It has been shown that NRG1 signalling can affect NMDAR levels and function, particularly phosphorylation of the NR2 subunits. However little is known about the possible effects of NMDAR dysfunction on NRG1 signalling, which is important with regards to schizophrenia aetiology as numerous risk factors for the disorder can alter NMDAR functioning during early brain development. This review focuses on the role of the NMDA receptor subunits and NRG1 signalling in schizophrenia and proposes a mechanism by which a disruption to the NMDAR, particularly via altering the balance of NR2 subunits during early development, could influence NRG1 signalling.

Publication Date


  • 2011

Citation


  • Geddes, A. E., Huang, X. & Newell, K. A. (2011). Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35 (4), 896-904.

Scopus Eid


  • 2-s2.0-79955982541

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4602&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3550

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 896

End Page


  • 904

Volume


  • 35

Issue


  • 4

Abstract


  • Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate

    receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that

    have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and

    functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and

    protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the functioning of the other. It has been shown that NRG1 signalling can affect NMDAR levels and function, particularly phosphorylation of the NR2 subunits. However little is known about the possible effects of NMDAR dysfunction on NRG1 signalling, which is important with regards to schizophrenia aetiology as numerous risk factors for the disorder can alter NMDAR functioning during early brain development. This review focuses on the role of the NMDA receptor subunits and NRG1 signalling in schizophrenia and proposes a mechanism by which a disruption to the NMDAR, particularly via altering the balance of NR2 subunits during early development, could influence NRG1 signalling.

Publication Date


  • 2011

Citation


  • Geddes, A. E., Huang, X. & Newell, K. A. (2011). Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35 (4), 896-904.

Scopus Eid


  • 2-s2.0-79955982541

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4602&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3550

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 896

End Page


  • 904

Volume


  • 35

Issue


  • 4