Skip to main content
placeholder image

G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension

Journal Article


Abstract


  • Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of GRK-4 have been linked to impaired natriuresis and salt-sensitive hypertension. The purpose of this report was to determine the effect of GRK-4 gene polymorphisms on the blood pressure (BP) responses to dietary intervention. Black subjects aged 50-75 years with mild-to-moderate hypertension were randomised to an 8-week dietary intervention (n = 40) or standard diet (n = 40). BP was measured at baseline and at 8 weeks using 24-h ambulatory BP. All subjects underwent DNA analysis for the R65L and A142V polymorphisms. Data were analysed using generalised linear models. For the whole group, between-diet differences in mean 24-h ambulatory systolic BP was -4.53 mm Hg (95% confidence interval -9.05 to -0.01, P = 0.05). In the intervention arm, the combined CC and CT group of the A142V showed a significant reduction in both systolic and diastolic ambulatory BP (-10 mm Hg, P = 0.023 and -6.5 mm Hg, P= 0.01, respectively), whereas the TT group demonstrated no reduction. Similarly, the combined GG and GT groups of the R65L showed a significant reduction in ambulatory BP (-10.6 mm Hg for systolic, P = 0.004 and 5.8 mm Hg for diastolic, P= 0.006). There was no response in the TT group. GRK-4 polymorphisms predict BP response to dietary modification in Black subjects with mild-to-moderate hypertension. These data may provide at least one among a range of clinical tools to target selected hypertensives to dietary intervention.

Authors


  •   Rayner, Brian (external author)
  •   Ramesar, R (external author)
  •   Steyn, Krisela (external author)
  •   Levitt, Naomi (external author)
  •   Lombard, Carl J. (external author)
  •   Charlton, Karen E.

Publication Date


  • 2012

Citation


  • Rayner, B., Ramesar, R., Steyn, K., Levitt, N., Lombard, C. & Charlton, K. (2012). G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension. Journal of Human Hypertension, 26 (5), 334-339.

Scopus Eid


  • 2-s2.0-84859803725

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2898

Number Of Pages


  • 5

Start Page


  • 334

End Page


  • 339

Volume


  • 26

Issue


  • 5

Abstract


  • Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of GRK-4 have been linked to impaired natriuresis and salt-sensitive hypertension. The purpose of this report was to determine the effect of GRK-4 gene polymorphisms on the blood pressure (BP) responses to dietary intervention. Black subjects aged 50-75 years with mild-to-moderate hypertension were randomised to an 8-week dietary intervention (n = 40) or standard diet (n = 40). BP was measured at baseline and at 8 weeks using 24-h ambulatory BP. All subjects underwent DNA analysis for the R65L and A142V polymorphisms. Data were analysed using generalised linear models. For the whole group, between-diet differences in mean 24-h ambulatory systolic BP was -4.53 mm Hg (95% confidence interval -9.05 to -0.01, P = 0.05). In the intervention arm, the combined CC and CT group of the A142V showed a significant reduction in both systolic and diastolic ambulatory BP (-10 mm Hg, P = 0.023 and -6.5 mm Hg, P= 0.01, respectively), whereas the TT group demonstrated no reduction. Similarly, the combined GG and GT groups of the R65L showed a significant reduction in ambulatory BP (-10.6 mm Hg for systolic, P = 0.004 and 5.8 mm Hg for diastolic, P= 0.006). There was no response in the TT group. GRK-4 polymorphisms predict BP response to dietary modification in Black subjects with mild-to-moderate hypertension. These data may provide at least one among a range of clinical tools to target selected hypertensives to dietary intervention.

Authors


  •   Rayner, Brian (external author)
  •   Ramesar, R (external author)
  •   Steyn, Krisela (external author)
  •   Levitt, Naomi (external author)
  •   Lombard, Carl J. (external author)
  •   Charlton, Karen E.

Publication Date


  • 2012

Citation


  • Rayner, B., Ramesar, R., Steyn, K., Levitt, N., Lombard, C. & Charlton, K. (2012). G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension. Journal of Human Hypertension, 26 (5), 334-339.

Scopus Eid


  • 2-s2.0-84859803725

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2898

Number Of Pages


  • 5

Start Page


  • 334

End Page


  • 339

Volume


  • 26

Issue


  • 5