Gellan gum doped polypyrrole neural prosthetic electrode coatings

Journal Article


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Abstract


  • Surface modification of neural prosthetic electrodes with polymeric materials, in particular, conducting

    polymers and hydrogels, has the potential to circumvent many problems associated with currently used

    electrode platforms. These problems include the disparity in mechanical properties between implanted

    electrodes and host neural tissue and the lack of biofunctionality at the electrode surface, both of which

    dissuade favourable reception of the implanted device. We have developed conducting polymer

    electrode coatings doped with the polysaccharide gellan gum, as a platform for improved functionality

    of neural prosthetic electrodes. Our electrode coatings, prepared by galvanostatic

    electropolymerisation, significantly reduced the impedance magnitude at frequencies relevant to neural

    cells, relative to uncoated gold Mylar electrodes (24 3 U at 1 kHz). Cyclic voltammetry was used to

    explore the electrochemical stability of the coatings, which lose only 23 2% charge carrying capacity

    when subjected to 400 redox cycles. The coatings show no change in impedance magnitude at 1 kHz

    when subject to 32 h of clinically relevant charge balanced current stimulation.

Publication Date


  • 2011

Citation


  • Higgins, T. M., Moulton, S. E., Gilmore, K. J., Wallace, G. G. & in het Panhuis, M. (2011). Gellan gum doped polypyrrole neural prosthetic electrode coatings. Soft Matter, 7 (10), 4690-4695.

Scopus Eid


  • 2-s2.0-79955652913

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2081&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1015

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 4690

End Page


  • 4695

Volume


  • 7

Issue


  • 10

Abstract


  • Surface modification of neural prosthetic electrodes with polymeric materials, in particular, conducting

    polymers and hydrogels, has the potential to circumvent many problems associated with currently used

    electrode platforms. These problems include the disparity in mechanical properties between implanted

    electrodes and host neural tissue and the lack of biofunctionality at the electrode surface, both of which

    dissuade favourable reception of the implanted device. We have developed conducting polymer

    electrode coatings doped with the polysaccharide gellan gum, as a platform for improved functionality

    of neural prosthetic electrodes. Our electrode coatings, prepared by galvanostatic

    electropolymerisation, significantly reduced the impedance magnitude at frequencies relevant to neural

    cells, relative to uncoated gold Mylar electrodes (24 3 U at 1 kHz). Cyclic voltammetry was used to

    explore the electrochemical stability of the coatings, which lose only 23 2% charge carrying capacity

    when subjected to 400 redox cycles. The coatings show no change in impedance magnitude at 1 kHz

    when subject to 32 h of clinically relevant charge balanced current stimulation.

Publication Date


  • 2011

Citation


  • Higgins, T. M., Moulton, S. E., Gilmore, K. J., Wallace, G. G. & in het Panhuis, M. (2011). Gellan gum doped polypyrrole neural prosthetic electrode coatings. Soft Matter, 7 (10), 4690-4695.

Scopus Eid


  • 2-s2.0-79955652913

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2081&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1015

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 4690

End Page


  • 4695

Volume


  • 7

Issue


  • 10