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Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans

Journal Article


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Abstract


  • A new stemofoline alkaloid, (2′S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known

    compounds stemofoline (1), (2′S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin

    F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new

    compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and

    semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active

    than 1′,2′-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities.

    Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL.

UOW Authors


  •   Sastraruji, Thanapat (external author)
  •   Chaiyong, Sukanda (external author)
  •   Jatisatienr, Araya (external author)
  •   Pyne, Stephen
  •   Ung, Alison T. (external author)
  •   Lie, Wilford

Publication Date


  • 2011

Citation


  • Sastraruji, T., Chaiyong, S., Jatisatienr, A., Pyne, S. G., Ung, A. T. & Lie, W. (2011). Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans. Journal of Natural Products, 74 (1), 60-64.

Scopus Eid


  • 2-s2.0-79951545662

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2208&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1141

Number Of Pages


  • 4

Start Page


  • 60

End Page


  • 64

Volume


  • 74

Issue


  • 1

Abstract


  • A new stemofoline alkaloid, (2′S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known

    compounds stemofoline (1), (2′S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin

    F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new

    compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and

    semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active

    than 1′,2′-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities.

    Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL.

UOW Authors


  •   Sastraruji, Thanapat (external author)
  •   Chaiyong, Sukanda (external author)
  •   Jatisatienr, Araya (external author)
  •   Pyne, Stephen
  •   Ung, Alison T. (external author)
  •   Lie, Wilford

Publication Date


  • 2011

Citation


  • Sastraruji, T., Chaiyong, S., Jatisatienr, A., Pyne, S. G., Ung, A. T. & Lie, W. (2011). Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans. Journal of Natural Products, 74 (1), 60-64.

Scopus Eid


  • 2-s2.0-79951545662

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2208&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1141

Number Of Pages


  • 4

Start Page


  • 60

End Page


  • 64

Volume


  • 74

Issue


  • 1