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Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age

Journal Article


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Abstract


  • Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating schizophrenia symptoms.

Publication Date


  • 2011

Citation


  • Frank, E. T., Newell, K. A. & Huang, X. (2011). Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age. Schizophrenia Research, 128 (1-3), 56-60.

Scopus Eid


  • 2-s2.0-79955485335

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4572&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3520

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 56

End Page


  • 60

Volume


  • 128

Issue


  • 1-3

Abstract


  • Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating schizophrenia symptoms.

Publication Date


  • 2011

Citation


  • Frank, E. T., Newell, K. A. & Huang, X. (2011). Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age. Schizophrenia Research, 128 (1-3), 56-60.

Scopus Eid


  • 2-s2.0-79955485335

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4572&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3520

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 56

End Page


  • 60

Volume


  • 128

Issue


  • 1-3